Unraveling the epigenetic fabric of type 2 diabetes mellitus: pathogenic mechanisms and therapeutic implications

• Published in: Frontiers in endocrinology (Lausanne) Vol. 15; p. 1295967
• Main Authors: Jazieh, Cham, Arabi, Tarek Ziad, Asim, Zohaib, Sabbah, Belal Nedal, Alsaud, Aljohara Waleed, Alkattan, Khaled, Yaqinuddin, Ahmed
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2024
• Subjects: beta-cell dysfunction; diabetes mellitus; Diabetes Mellitus, Type 2 - genetics; Diet; DNA Methylation; Endocrinology; Epigenesis, Genetic; epigenetics; Humans; insulin resistance; obesity; Obesity - complications; type 2 diabetes complications; cellular senescence; diabetes mellitus; mitochondrial dysfunction; beta-cell dysfunction; insulin resistance; epigenetics; obesity; type 2 diabetes complications

Type 2 diabetes mellitus (T2DM) is a rapidly escalating global health concern, with its prevalence projected to increase significantly in the near future. This review delves into the intricate role of epigenetic modifications - including DNA methylation, histone acetylation, and micro-ribonucleic ac...