Oral microbiota and biliary tract cancers: unveiling hidden mechanistic links
Biliary tract cancers (BTCs), a group of rare aggressive malignancies, posed significant clinical challenges due to late diagnosis and limited therapies. While gut microbiota had been extensively studied in gastrointestinal cancers, the role of oral microbiota—a primary microbial reservoir entering...
Saved in:
| Published in | Frontiers in oncology Vol. 15; p. 1585923 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
11.06.2025
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Biliary tract cancers (BTCs), a group of rare aggressive malignancies, posed significant clinical challenges due to late diagnosis and limited therapies. While gut microbiota had been extensively studied in gastrointestinal cancers, the role of oral microbiota—a primary microbial reservoir entering the digestive system—remained poorly understood. Emerging evidence indicated that oral bacteria might affect biliary carcinogenesis through direct colonization, immune modulation, and metabolic interactions via the oral-gut-liver axis. This narrative review analyzed current research connecting oral microbial imbalance with BTCs. It explored how bacterial translocation, inflammatory metabolites, and immune alterations could promote cancer development. Established BTC risk factors—including gallstones, primary sclerosing cholangitis, cirrhosis, and H. pylori infection—were evaluated for their associations with oral microbiota changes. Epidemiological studies revealed that periodontal disease and poor oral hygiene elevated BTC risk. Sequencing analyses identified oral-origin bacteria ( Prevotella , Fusobacterium , Streptococcus ) in bile and tumor tissues, suggesting microbial migration through swallowing or bloodstream. Mechanistic investigations showed microbial components (e.g., lipopolysaccharides, membrane vesicles) activated inflammatory pathways (TLR4/NF-κB, STAT3) and modified immune checkpoints, while metabolites potentially altered biliary cell metabolism. Different studies have found variable changes in oral microbiota in the presence of BTCs, thus a novel “biphasic dysbiosis” hypothesis was proposed to explain differing oral microbial diversity patterns across BTC subtypes. Despite progress, critical knowledge gaps persisted regarding causality, spatial microbial variations, and functional impacts of metabolites in BTCs. Future research was recommended to employ multi-omics approaches, single-cell analysis, and AI tools to enhance early detection and prevention strategies. |
|---|---|
| AbstractList | Biliary tract cancers (BTCs), a group of rare aggressive malignancies, posed significant clinical challenges due to late diagnosis and limited therapies. While gut microbiota had been extensively studied in gastrointestinal cancers, the role of oral microbiota-a primary microbial reservoir entering the digestive system-remained poorly understood. Emerging evidence indicated that oral bacteria might affect biliary carcinogenesis through direct colonization, immune modulation, and metabolic interactions via the oral-gut-liver axis. This narrative review analyzed current research connecting oral microbial imbalance with BTCs. It explored how bacterial translocation, inflammatory metabolites, and immune alterations could promote cancer development. Established BTC risk factors-including gallstones, primary sclerosing cholangitis, cirrhosis, and
infection-were evaluated for their associations with oral microbiota changes. Epidemiological studies revealed that periodontal disease and poor oral hygiene elevated BTC risk. Sequencing analyses identified oral-origin bacteria (
,
,
) in bile and tumor tissues, suggesting microbial migration through swallowing or bloodstream. Mechanistic investigations showed microbial components (e.g., lipopolysaccharides, membrane vesicles) activated inflammatory pathways (TLR4/NF-κB, STAT3) and modified immune checkpoints, while metabolites potentially altered biliary cell metabolism. Different studies have found variable changes in oral microbiota in the presence of BTCs, thus a novel "biphasic dysbiosis" hypothesis was proposed to explain differing oral microbial diversity patterns across BTC subtypes. Despite progress, critical knowledge gaps persisted regarding causality, spatial microbial variations, and functional impacts of metabolites in BTCs. Future research was recommended to employ multi-omics approaches, single-cell analysis, and AI tools to enhance early detection and prevention strategies. Biliary tract cancers (BTCs), a group of rare aggressive malignancies, posed significant clinical challenges due to late diagnosis and limited therapies. While gut microbiota had been extensively studied in gastrointestinal cancers, the role of oral microbiota—a primary microbial reservoir entering the digestive system—remained poorly understood. Emerging evidence indicated that oral bacteria might affect biliary carcinogenesis through direct colonization, immune modulation, and metabolic interactions via the oral-gut-liver axis. This narrative review analyzed current research connecting oral microbial imbalance with BTCs. It explored how bacterial translocation, inflammatory metabolites, and immune alterations could promote cancer development. Established BTC risk factors—including gallstones, primary sclerosing cholangitis, cirrhosis, and H. pylori infection—were evaluated for their associations with oral microbiota changes. Epidemiological studies revealed that periodontal disease and poor oral hygiene elevated BTC risk. Sequencing analyses identified oral-origin bacteria (Prevotella, Fusobacterium, Streptococcus) in bile and tumor tissues, suggesting microbial migration through swallowing or bloodstream. Mechanistic investigations showed microbial components (e.g., lipopolysaccharides, membrane vesicles) activated inflammatory pathways (TLR4/NF-κB, STAT3) and modified immune checkpoints, while metabolites potentially altered biliary cell metabolism. Different studies have found variable changes in oral microbiota in the presence of BTCs, thus a novel “biphasic dysbiosis” hypothesis was proposed to explain differing oral microbial diversity patterns across BTC subtypes. Despite progress, critical knowledge gaps persisted regarding causality, spatial microbial variations, and functional impacts of metabolites in BTCs. Future research was recommended to employ multi-omics approaches, single-cell analysis, and AI tools to enhance early detection and prevention strategies. Biliary tract cancers (BTCs), a group of rare aggressive malignancies, posed significant clinical challenges due to late diagnosis and limited therapies. While gut microbiota had been extensively studied in gastrointestinal cancers, the role of oral microbiota—a primary microbial reservoir entering the digestive system—remained poorly understood. Emerging evidence indicated that oral bacteria might affect biliary carcinogenesis through direct colonization, immune modulation, and metabolic interactions via the oral-gut-liver axis. This narrative review analyzed current research connecting oral microbial imbalance with BTCs. It explored how bacterial translocation, inflammatory metabolites, and immune alterations could promote cancer development. Established BTC risk factors—including gallstones, primary sclerosing cholangitis, cirrhosis, and H. pylori infection—were evaluated for their associations with oral microbiota changes. Epidemiological studies revealed that periodontal disease and poor oral hygiene elevated BTC risk. Sequencing analyses identified oral-origin bacteria ( Prevotella , Fusobacterium , Streptococcus ) in bile and tumor tissues, suggesting microbial migration through swallowing or bloodstream. Mechanistic investigations showed microbial components (e.g., lipopolysaccharides, membrane vesicles) activated inflammatory pathways (TLR4/NF-κB, STAT3) and modified immune checkpoints, while metabolites potentially altered biliary cell metabolism. Different studies have found variable changes in oral microbiota in the presence of BTCs, thus a novel “biphasic dysbiosis” hypothesis was proposed to explain differing oral microbial diversity patterns across BTC subtypes. Despite progress, critical knowledge gaps persisted regarding causality, spatial microbial variations, and functional impacts of metabolites in BTCs. Future research was recommended to employ multi-omics approaches, single-cell analysis, and AI tools to enhance early detection and prevention strategies. Biliary tract cancers (BTCs), a group of rare aggressive malignancies, posed significant clinical challenges due to late diagnosis and limited therapies. While gut microbiota had been extensively studied in gastrointestinal cancers, the role of oral microbiota-a primary microbial reservoir entering the digestive system-remained poorly understood. Emerging evidence indicated that oral bacteria might affect biliary carcinogenesis through direct colonization, immune modulation, and metabolic interactions via the oral-gut-liver axis. This narrative review analyzed current research connecting oral microbial imbalance with BTCs. It explored how bacterial translocation, inflammatory metabolites, and immune alterations could promote cancer development. Established BTC risk factors-including gallstones, primary sclerosing cholangitis, cirrhosis, and H. pylori infection-were evaluated for their associations with oral microbiota changes. Epidemiological studies revealed that periodontal disease and poor oral hygiene elevated BTC risk. Sequencing analyses identified oral-origin bacteria (Prevotella, Fusobacterium, Streptococcus) in bile and tumor tissues, suggesting microbial migration through swallowing or bloodstream. Mechanistic investigations showed microbial components (e.g., lipopolysaccharides, membrane vesicles) activated inflammatory pathways (TLR4/NF-κB, STAT3) and modified immune checkpoints, while metabolites potentially altered biliary cell metabolism. Different studies have found variable changes in oral microbiota in the presence of BTCs, thus a novel "biphasic dysbiosis" hypothesis was proposed to explain differing oral microbial diversity patterns across BTC subtypes. Despite progress, critical knowledge gaps persisted regarding causality, spatial microbial variations, and functional impacts of metabolites in BTCs. Future research was recommended to employ multi-omics approaches, single-cell analysis, and AI tools to enhance early detection and prevention strategies.Biliary tract cancers (BTCs), a group of rare aggressive malignancies, posed significant clinical challenges due to late diagnosis and limited therapies. While gut microbiota had been extensively studied in gastrointestinal cancers, the role of oral microbiota-a primary microbial reservoir entering the digestive system-remained poorly understood. Emerging evidence indicated that oral bacteria might affect biliary carcinogenesis through direct colonization, immune modulation, and metabolic interactions via the oral-gut-liver axis. This narrative review analyzed current research connecting oral microbial imbalance with BTCs. It explored how bacterial translocation, inflammatory metabolites, and immune alterations could promote cancer development. Established BTC risk factors-including gallstones, primary sclerosing cholangitis, cirrhosis, and H. pylori infection-were evaluated for their associations with oral microbiota changes. Epidemiological studies revealed that periodontal disease and poor oral hygiene elevated BTC risk. Sequencing analyses identified oral-origin bacteria (Prevotella, Fusobacterium, Streptococcus) in bile and tumor tissues, suggesting microbial migration through swallowing or bloodstream. Mechanistic investigations showed microbial components (e.g., lipopolysaccharides, membrane vesicles) activated inflammatory pathways (TLR4/NF-κB, STAT3) and modified immune checkpoints, while metabolites potentially altered biliary cell metabolism. Different studies have found variable changes in oral microbiota in the presence of BTCs, thus a novel "biphasic dysbiosis" hypothesis was proposed to explain differing oral microbial diversity patterns across BTC subtypes. Despite progress, critical knowledge gaps persisted regarding causality, spatial microbial variations, and functional impacts of metabolites in BTCs. Future research was recommended to employ multi-omics approaches, single-cell analysis, and AI tools to enhance early detection and prevention strategies. |
| Author | Zhang, Shu Zhang, Yuhan |
| AuthorAffiliation | 1 Nursing Department, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China 2 College of Stomatology, Chongqing Medical University , Chongqing , China |
| AuthorAffiliation_xml | – name: 2 College of Stomatology, Chongqing Medical University , Chongqing , China – name: 1 Nursing Department, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China |
| Author_xml | – sequence: 1 givenname: Yuhan surname: Zhang fullname: Zhang, Yuhan – sequence: 2 givenname: Shu surname: Zhang fullname: Zhang, Shu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40567604$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVkU1vVCEUholpY2vtD3BjWLqZkW8uboxprDZp040m7ghzgBnqvVDhThP_fRlnbFo2kHPePOeQ5w06yiUHhN5RsuR8MB9jybBkhMkllYM0jL9Cp4xxsTCC_zp69j5B563dkX6UJJTw1-hEEKm0IuIU3dxWN-IpQS2rVGaHXfZ4lcbk6l88VwczBpch1PYJb_ND6J28xpvkfch4CrBxObU5Ae713-0tOo5ubOH8cJ-hn5dff1x8X1zffru6-HK9AMHIvNCShyiArQbjTXRUct95XukAVGg1sOjMoIzRhAvXwypABEkNxKANY4afoas91xd3Z-9rmvq6trhk_xVKXVtX-1ZjsF4RTYnmRnMQMgonYRCKSq8UuEBEZ33es-63qyl4CLl_e3wBfdnJaWPX5cFSRgetxNAJHw6EWv5sQ5vtlBqEcXQ5lG2znDHBFFFC9ej758OepvwX0gN0H-hCWqshPkUosTvvdufd7rzbg3f-CAJboOs |
| Cites_doi | 10.1080/19490976.2024.2388801 10.1016/j.tim.2020.11.004 10.1111/odi.13044 10.1158/1055-9965.EPI-17-0212 10.1016/S0140-6736(21)00153-7 10.1111/liv.15152 10.1038/nature13568 10.1016/j.jhep.2021.02.011 10.1155/2019/1092563 10.1016/j.amjsurg.2006.08.001 10.1126/science.aan4526 10.1038/srep17450 10.1093/ecco-jcc/jjae190.0065 10.1007/s00253-022-12333-y 10.3389/fcimb.2021.606986 10.1128/JCM.43.11.5721-5732.2005 10.1002/hep.27819 10.3390/ijms25136971 10.1186/s12866-020-01801-y 10.1002/hep.25704 10.1186/s12879-015-0977-x 10.1016/j.micinf.2023.105250 10.1371/journal.pone.0150519 10.1016/j.isci.2024.109294 10.1186/s40364-024-00607-8 10.1177/1073274817729245 10.1158/1940-6207.CAPR-16-0249 10.1038/s41575-018-0011-z 10.1126/science.aan5931 10.1186/s40001-023-01308-y 10.1111/odi.14785 10.1038/nrg3182 10.1055/s-0037-1608801 10.1016/j.chembiol.2024.10.013 10.1158/0008-5472.CAN-12-0122 10.1023/A:1013747228572 10.1016/j.jinf.2022.02.020 10.1038/s41522-024-00511-x 10.37349/emed.2024.00241 10.3390/ijms241713470 10.1007/s12072-020-10089-z 10.1186/s40168-019-0712-8 10.3748/wjg.v23.i25.4548 10.1136/gutjnl-2016-312904 10.1111/apt.15375 10.1038/s41598-018-28905-w 10.1080/19490976.2023.2201159 10.1016/j.ebiom.2016.04.034 10.3390/microorganisms13010119 10.1177/20506406198580433 10.1111/prd.12387 10.1007/s11894-005-0051-8 10.1073/pnas.1409644111 10.1038/ismej.2010.30 10.1200/JCO.18.02178 10.1038/nrmicro3344 10.1152/ajpgi.00230.2018 10.1159/000490829 10.1128/JB.00542-10 10.3389/fcimb.2022.914418 10.3389/fmicb.2023.1288525 10.1016/j.pan.2018.09.004 10.1038/s41598-022-17917-2 10.1186/s40168-020-00875-0 10.1186/s12967-024-05989-9 10.1097/MEG.0000000000000885 10.1186/s40779-022-00423-x 10.1136/gutjnl-2015-310101 10.1080/20002297.2025.2487645 10.1038/nrgastro.2011.131 10.1016/j.cmi.2015.10.008 10.1186/1471-2458-14-1110 10.1097/MEG.0b013e32835c0362 10.1111/hel.12786 |
| ContentType | Journal Article |
| Copyright | Copyright © 2025 Zhang and Zhang. Copyright © 2025 Zhang and Zhang 2025 Zhang and Zhang |
| Copyright_xml | – notice: Copyright © 2025 Zhang and Zhang. – notice: Copyright © 2025 Zhang and Zhang 2025 Zhang and Zhang |
| DBID | AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.3389/fonc.2025.1585923 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2234-943X |
| ExternalDocumentID | oai_doaj_org_article_d6071073973c45f4a5c84615d66cae04 PMC12187648 40567604 10_3389_fonc_2025_1585923 |
| Genre | Journal Article Review |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ACXDI ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EBS EJD EMOBN GROUPED_DOAJ GX1 HYE KQ8 M~E OK1 PGMZT RNS RPM IPNFZ M48 NPM RIG 7X8 5PM |
| ID | FETCH-LOGICAL-c420t-753ef4c2b89d9fa153ddded67ec147682fa986997034a7536ecfc519cfe792293 |
| IEDL.DBID | DOA |
| ISSN | 2234-943X |
| IngestDate | Wed Aug 27 01:28:13 EDT 2025 Thu Aug 21 18:32:49 EDT 2025 Thu Jun 26 17:30:36 EDT 2025 Sat Jun 28 01:34:20 EDT 2025 Thu Jul 03 08:37:31 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | biliary tract cancer bacterial translocation oral microbiota mechanisms oncogenic bacteria |
| Language | English |
| License | Copyright © 2025 Zhang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c420t-753ef4c2b89d9fa153ddded67ec147682fa986997034a7536ecfc519cfe792293 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Reviewed by: Shintaro Nakajima, California Institute of Technology, United States Zhengqi Li, China-Japan Friendship Hospital, China Oriana Lo Re, Mediterranean Institute for Transplantation and Highly Specialized Therapies (ISMETT), Italy Edited by: Soumyadev Sarkar, Arizona State University, United States |
| OpenAccessLink | https://doaj.org/article/d6071073973c45f4a5c84615d66cae04 |
| PMID | 40567604 |
| PQID | 3224260646 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_d6071073973c45f4a5c84615d66cae04 pubmedcentral_primary_oai_pubmedcentral_nih_gov_12187648 proquest_miscellaneous_3224260646 pubmed_primary_40567604 crossref_primary_10_3389_fonc_2025_1585923 |
| PublicationCentury | 2000 |
| PublicationDate | 2025-06-11 |
| PublicationDateYYYYMMDD | 2025-06-11 |
| PublicationDate_xml | – month: 06 year: 2025 text: 2025-06-11 day: 11 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Frontiers in oncology |
| PublicationTitleAlternate | Front Oncol |
| PublicationYear | 2025 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Leão (B33) 2023; 107 Zhu (B41) 2024; 12 Schulz (B70) 2018; 67 Yang (B72) 2023; 15 Molinero (B29) 2019; 7 Yao (B17) 2024; 26 Yu (B25) 2014; 14 Chng (B32) 2016; 8 Bik (B20) 2010; 4 Lapidot (B57) 2021; 15 Zhou (B40) 2018; 47 Bajaj (B62) 2018; 315 Valle (B5) 2021; 397 Qiao (B59) 2024; 30 Ye (B52) 2016; 11 Mehal (B37) 2012; 55 Zhang (B74) 2024; 27 Dewhirst (B34) 2010; 192 Atarashi (B21) 2017; 358 Tsen (B45) 2018; 18 Díaz-Basabe (B16) 2024; 16 Ohtsu (B22) 2019; 25 Mima (B14) 2016; 65 Louis (B9) 2014; 12 Lu (B64) 2015; 15 Freire (B13) 2021; 29 Aas (B19) 2005; 43 Berg (B1) 2020; 8 Jordão (B27) 2019; 7 Stewart (B49) 2006; 192 Shroff (B6) 2019; 37 Cai (B46) 2024; 10 Qin (B66) 2014; 513 Qiu (B39) 2021; 11 Sato (B60) 2022; 12 Oh (B43) 2025; 23 Wang (B15) 2025; 19 Jia (B65) 2022; 84 Eren (B18) 2014; 111 Desjonqueres (B58) 2022; 42 Bajer (B56) 2017; 23 Tripathi (B23) 2018; 15 Caselli (B4) 2020; 20 Denefil (B11) 2024; 5 Boyer (B28) 2021; 75 Zhou (B68) 2013; 25 Bhandari (B50) 2017; 29 Avilés-Jiménez (B35) 2016; 22 Rao (B42) 2022; 9 Hov (B54) 2017; 37 Rühlemann (B55) 2019; 50 Uguz (B36) 2025; 13 Chen (B71) 2022; 12 Kuraji (B12) 2021; 2000 Li (B30) 2022; 14 Wu (B69) 2021; 26 Rebeck (B75) 2025; 32 Chen (B38) 2023; 14 Ma (B73) 2025; 17 Donato (B44) 2001; 12 Sato (B67) 2023; 24 Cai (B53) 2023; 28 Jensen (B61) 2018; 8 Massarweh (B48) 2017; 24 Shen (B51) 2015; 5 Bajaj (B63) 2015; 62 Rajagopala (B2) 2017; 10 Maiuolo (B10) 2024; 25 Chen (B31) 2019; 2019 Ma (B24) 2018; 360 Blechacz (B7) 2011; 8 Cho (B3) 2012; 13 Swartz (B8) 2012; 72 Shaffer (B47) 2005; 7 Nwizu (B26) 2017; 26 |
| References_xml | – volume: 16 year: 2024 ident: B16 article-title: Porphyromonas gingivalis fuels colorectal cancer through CHI3L1-mediated iNKT cell-driven immune evasion publication-title: Gut Microbes doi: 10.1080/19490976.2024.2388801 – volume: 29 year: 2021 ident: B13 article-title: The Oral Host-Microbial Interactome: An Ecological Chronometer of Health publication-title: Trends Microbiol doi: 10.1016/j.tim.2020.11.004 – volume: 25 year: 2019 ident: B22 article-title: Influence of Porphyromonas gingivalis in gut microbiota of streptozotocin-induced diabetic mice publication-title: Oral Dis doi: 10.1111/odi.13044 – volume: 26 year: 2017 ident: B26 article-title: Periodontal Disease and Incident Cancer Risk among Postmenopausal Women: Results from the Women’s Health Initiative Observational Cohort publication-title: Cancer Epidemiol Biomarkers Prev doi: 10.1158/1055-9965.EPI-17-0212 – volume: 397 year: 2021 ident: B5 article-title: Biliary tract cancer publication-title: Lancet doi: 10.1016/S0140-6736(21)00153-7 – volume: 42 start-page: 492 year: 2022 ident: B58 article-title: Preneoplastic lesions in the liver: Molecular insights and relevance for clinical practice publication-title: Liver Int doi: 10.1111/liv.15152 – volume: 513 start-page: 59 year: 2014 ident: B66 article-title: Alterations of the human gut microbiome in liver cirrhosis publication-title: Nature doi: 10.1038/nature13568 – volume: 75 start-page: 190 year: 2021 ident: B28 article-title: Bile formation and secretion: An update publication-title: J Hepatol doi: 10.1016/j.jhep.2021.02.011 – volume: 2019 year: 2019 ident: B31 article-title: A Preliminary Study of Biliary Microbiota in Patients with Bile Duct Stones or Distal Cholangiocarcinoma publication-title: BioMed Res Int doi: 10.1155/2019/1092563 – volume: 192 start-page: 598 year: 2006 ident: B49 article-title: Biliary bacterial factors determine the path of gallstone formation publication-title: Am J Surg doi: 10.1016/j.amjsurg.2006.08.001 – volume: 358 year: 2017 ident: B21 article-title: Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation publication-title: Science doi: 10.1126/science.aan4526 – volume: 5 year: 2015 ident: B51 article-title: Metagenomic sequencing of bile from gallstone patients to identify different microbial community patterns and novel biliary bacteria publication-title: Sci Rep doi: 10.1038/srep17450 – volume: 19 start-page: i136 year: 2025 ident: B15 article-title: DOP026 Porphyromonas gingivalis secreted htpG disrupts TLR4/PAPSS2-mediated mucin sulfation and aggravates ulcerative colitis publication-title: J Crohn’s Colitis doi: 10.1093/ecco-jcc/jjae190.0065 – volume: 107 year: 2023 ident: B33 article-title: Pseudomonadota in the oral cavity: a glimpse into the environment-human nexus publication-title: Appl Microbiol Biotechnol doi: 10.1007/s00253-022-12333-y – volume: 11 year: 2021 ident: B39 article-title: Lipopolysaccharide Preparation Derived From Porphyromonas gingivalis Induces a Weaker Immuno-Inflammatory Response in BV-2 Microglial Cells Than Escherichia coli by Differentially Activating TLR2/4-Mediated NF-κB/STAT3 Signaling Pathways publication-title: Front Cell Infect Microbiol doi: 10.3389/fcimb.2021.606986 – volume: 43 year: 2005 ident: B19 article-title: Defining the Normal Bacterial Flora of the Oral Cavity publication-title: J Clin Microbiol doi: 10.1128/JCM.43.11.5721-5732.2005 – volume: 62 start-page: 1260 year: 2015 ident: B63 article-title: Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy publication-title: Hepatology doi: 10.1002/hep.27819 – volume: 25 year: 2024 ident: B10 article-title: The Postbiotic Properties of Butyrate in the Modulation of the Gut Microbiota: The Potential of Its Combination with Polyphenols and Dietary Fibers publication-title: Int J Mol Sci doi: 10.3390/ijms25136971 – volume: 20 start-page: 120 year: 2020 ident: B4 article-title: Defining the oral microbiome by whole-genome sequencing and resistome analysis: the complexity of the healthy picture publication-title: BMC Microbiol doi: 10.1186/s12866-020-01801-y – volume: 55 start-page: 1647 year: 2012 ident: B37 article-title: The gut-liver axis: A busy two-way street publication-title: Hepatology doi: 10.1002/hep.25704 – volume: 15 start-page: 239 year: 2015 ident: B64 article-title: Alterations of Bacteroides sp., Neisseria sp., Actinomyces sp., and Streptococcus sp. populations in the oropharyngeal microbiome are associated with liver cirrhosis and pneumonia publication-title: BMC Infect Dis doi: 10.1186/s12879-015-0977-x – volume: 26 year: 2024 ident: B17 article-title: Porphyromonas gingivalis as a promotor in the development of the alcoholic liver disease via ferroptosis publication-title: Microbes Infect doi: 10.1016/j.micinf.2023.105250 – volume: 11 start-page: e0150519 year: 2016 ident: B52 article-title: Influence of the Biliary System on Biliary Bacteria Revealed by Bacterial Communities of the Human Biliary and Upper Digestive Tracts publication-title: PLoS One doi: 10.1371/journal.pone.0150519 – volume: 27 year: 2024 ident: B74 article-title: Highly accurate diagnosis of pancreatic cancer by integrative modeling using gut microbiome and exposome data publication-title: iScience doi: 10.1016/j.isci.2024.109294 – volume: 12 start-page: 56 year: 2024 ident: B41 article-title: Gut microbiota and metabolites signatures of clinical response in anti-PD-1/PD-L1 based immunotherapy of biliary tract cancer publication-title: Biomark Res doi: 10.1186/s40364-024-00607-8 – volume: 24 year: 2017 ident: B48 article-title: Epidemiology of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma publication-title: Cancer Control doi: 10.1177/1073274817729245 – volume: 10 year: 2017 ident: B2 article-title: The Human Microbiome and Cancer publication-title: Cancer Prev Res doi: 10.1158/1940-6207.CAPR-16-0249 – volume: 15 start-page: 397 year: 2018 ident: B23 article-title: The gut-liver axis and the intersection with the microbiome publication-title: Nat Rev Gastroenterol Hepatol doi: 10.1038/s41575-018-0011-z – volume: 360 start-page: eaan5931 year: 2018 ident: B24 article-title: Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells publication-title: Science doi: 10.1126/science.aan5931 – volume: 28 start-page: 313 year: 2023 ident: B53 article-title: Variations of bile bacterial community alongside gallstone disease progression and key taxa involved in poor outcomes after endoscopic surgery publication-title: Eur J Med Res doi: 10.1186/s40001-023-01308-y – volume: 30 year: 2024 ident: B59 article-title: Periodontitis and NAFLD-related diseases: A bidirectional two-sample Mendelian randomization study publication-title: Oral Dis doi: 10.1111/odi.14785 – volume: 13 year: 2012 ident: B3 article-title: The Human Microbiome: at the interface of health and disease publication-title: Nat Rev Genet doi: 10.1038/nrg3182 – volume: 37 year: 2017 ident: B54 article-title: The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts publication-title: Semin Liver Dis doi: 10.1055/s-0037-1608801 – volume: 32 start-page: 98 year: 2025 ident: B75 article-title: A yeast-based oral therapeutic delivers immune checkpoint inhibitors to reduce intestinal tumor burden publication-title: Cell Chem Biol doi: 10.1016/j.chembiol.2024.10.013 – volume: 72 year: 2012 ident: B8 article-title: Tumor microenvironment complexity: emerging roles in cancer therapy publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-0122 – volume: 12 year: 2001 ident: B44 article-title: Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis: a case–control study in Italy publication-title: Cancer Causes Control doi: 10.1023/A:1013747228572 – volume: 84 year: 2022 ident: B65 article-title: Lantibiotic-encoding Streptococcus in the human microbiome are underlying risk factors for liver diseases publication-title: J Infect doi: 10.1016/j.jinf.2022.02.020 – volume: 10 start-page: 1 year: 2024 ident: B46 article-title: Integrative analysis reveals associations between oral microbiota dysbiosis and host genetic and epigenetic aberrations in oral cavity squamous cell carcinoma publication-title: NPJ Biofilms Microb doi: 10.1038/s41522-024-00511-x – volume: 5 year: 2024 ident: B11 article-title: Comparative analysis of dysbiotic changes in the oral cavity of patients with periodontal diseases and systemic pathologies publication-title: Explor Med doi: 10.37349/emed.2024.00241 – volume: 24 year: 2023 ident: B67 article-title: Effect of Liver Fibrosis on Oral and Gut Microbiota in the Japanese General Population Determined by Evaluating the FibroScan-Aspartate Aminotransferase Score publication-title: Int J Mol Sci doi: 10.3390/ijms241713470 – volume: 15 start-page: 191 year: 2021 ident: B57 article-title: Alterations of the salivary and fecal microbiome in patients with primary sclerosing cholangitis publication-title: Hepatol Int doi: 10.1007/s12072-020-10089-z – volume: 7 start-page: 100 year: 2019 ident: B29 article-title: The human gallbladder microbiome is related to the physiological state and the biliary metabolic profile publication-title: Microbiome doi: 10.1186/s40168-019-0712-8 – volume: 23 year: 2017 ident: B56 article-title: Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis publication-title: World J Gastroenterol doi: 10.3748/wjg.v23.i25.4548 – volume: 67 year: 2018 ident: B70 article-title: The active bacterial assemblages of the upper GI tract in individuals with and without Helicobacter infection publication-title: Gut doi: 10.1136/gutjnl-2016-312904 – volume: 50 year: 2019 ident: B55 article-title: Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis publication-title: Aliment Pharmacol Ther doi: 10.1111/apt.15375 – volume: 8 start-page: 10718 year: 2018 ident: B61 article-title: Unique subgingival microbiota associated with periodontitis in cirrhosis patients publication-title: Sci Rep doi: 10.1038/s41598-018-28905-w – volume: 15 year: 2023 ident: B72 article-title: A distinct microbiota signature precedes the clinical diagnosis of hepatocellular carcinoma publication-title: Gut Microbes doi: 10.1080/19490976.2023.2201159 – volume: 8 start-page: 195 year: 2016 ident: B32 article-title: Tissue Microbiome Profiling Identifies an Enrichment of Specific Enteric Bacteria in Opisthorchis viverrini Associated Cholangiocarcinoma publication-title: EBioMedicine doi: 10.1016/j.ebiom.2016.04.034 – volume: 13 year: 2025 ident: B36 article-title: Unveiling Microbiota Profiles in Saliva and Pancreatic Tissues of Patients with Pancreatic Cancer publication-title: Microorganisms doi: 10.3390/microorganisms13010119 – volume: 7 year: 2019 ident: B27 article-title: The association between self-reported poor oral health and gastrointestinal cancer risk in the UK Biobank: A large prospective cohort study publication-title: U Eur Gastroenterol J doi: 10.1177/20506406198580433 – volume: 2000 year: 2021 ident: B12 article-title: Periodontal disease–related nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: An emerging concept of oral-liver axis publication-title: Periodontol doi: 10.1111/prd.12387 – volume: 7 year: 2005 ident: B47 article-title: Epidemiology and risk factors for gallstone disease: Has the paradigm changed in the 21st century publication-title: Curr Gastroenterol Rep doi: 10.1007/s11894-005-0051-8 – volume: 111 year: 2014 ident: B18 article-title: Oligotyping analysis of the human oral microbiome publication-title: Proc Natl Acad Sci doi: 10.1073/pnas.1409644111 – volume: 4 year: 2010 ident: B20 article-title: Bacterial diversity in the oral cavity of ten healthy individuals publication-title: ISME J doi: 10.1038/ismej.2010.30 – volume: 37 year: 2019 ident: B6 article-title: Adjuvant Therapy for Resected Biliary Tract Cancer: ASCO Clinical Practice Guideline publication-title: JCO doi: 10.1200/JCO.18.02178 – volume: 12 year: 2014 ident: B9 article-title: The gut microbiota, bacterial metabolites and colorectal cancer publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro3344 – volume: 315 year: 2018 ident: B62 article-title: Periodontal therapy favorably modulates the oral-gut-hepatic axis in cirrhosis publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00230.2018 – volume: 47 year: 2018 ident: B40 article-title: Induction of Pro-Inflammatory Response via Activated Macrophage-Mediated NF-κB and STAT3 Pathways in Gastric Cancer Cells publication-title: Cell Physiol Biochem doi: 10.1159/000490829 – volume: 192 year: 2010 ident: B34 article-title: The human oral microbiome publication-title: J Bacteriol doi: 10.1128/JB.00542-10 – volume: 12 year: 2022 ident: B71 article-title: The interactions between oral-gut axis microbiota and Helicobacter pylori publication-title: Front Cell Infect Microbiol doi: 10.3389/fcimb.2022.914418 – volume: 14 year: 2023 ident: B38 article-title: Elucidating the causal association between gut microbiota and intrahepatic cholangiocarcinoma through Mendelian randomization analysis publication-title: Front Microbiol doi: 10.3389/fmicb.2023.1288525 – volume: 18 year: 2018 ident: B45 article-title: Dilemma of elevated CA 19–9 in biliary pathology publication-title: Pancreatology doi: 10.1016/j.pan.2018.09.004 – volume: 12 start-page: 13621 year: 2022 ident: B60 article-title: A cross-sectional study assessing the relationship between non-alcoholic fatty liver disease and periodontal disease publication-title: Sci Rep doi: 10.1038/s41598-022-17917-2 – volume: 8 start-page: 103 year: 2020 ident: B1 article-title: Microbiome definition re-visited: old concepts and new challenges publication-title: Microbiome doi: 10.1186/s40168-020-00875-0 – volume: 23 start-page: 20 year: 2025 ident: B43 article-title: Metagenomic characterization of oral microbiome signatures to predict upper gastrointestinal and pancreaticobiliary cancers: a case-control study publication-title: J Transl Med doi: 10.1186/s12967-024-05989-9 – volume: 29 start-page: 861 year: 2017 ident: B50 article-title: Association between oral hygiene and ultrasound-confirmed gallstone disease in US population publication-title: Eur J Gastroenterol Hepatol doi: 10.1097/MEG.0000000000000885 – volume: 9 start-page: 62 year: 2022 ident: B42 article-title: Alterations in the human oral microbiome in cholangiocarcinoma publication-title: Military Med Res doi: 10.1186/s40779-022-00423-x – volume: 65 year: 2016 ident: B14 article-title: Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis publication-title: Gut doi: 10.1136/gutjnl-2015-310101 – volume: 17 year: 2025 ident: B73 article-title: Tongue coating microbiota-based machine learning for diagnosing digestive system tumours publication-title: J Oral Microbiol doi: 10.1080/20002297.2025.2487645 – volume: 14 year: 2022 ident: B30 article-title: Characteristics of bile microbiota in cholelithiasis, perihilar cholangiocarcinoma, distal cholangiocarcinoma, and pancreatic cancer publication-title: Am J Transl Res – volume: 8 year: 2011 ident: B7 article-title: Clinical diagnosis and staging of cholangiocarcinoma publication-title: Nat Rev Gastroenterol Hepatol doi: 10.1038/nrgastro.2011.131 – volume: 22 start-page: 178.e11 year: 2016 ident: B35 article-title: Microbiota studies in the bile duct strongly suggest a role for Helicobacter pylori in extrahepatic cholangiocarcinoma publication-title: Clin Microbiol Infect doi: 10.1016/j.cmi.2015.10.008 – volume: 14 year: 2014 ident: B25 article-title: The association between the upper digestive tract microbiota by HOMIM and oral health in a population-based study in Linxian, China publication-title: BMC Public Health doi: 10.1186/1471-2458-14-1110 – volume: 25 start-page: 447 year: 2013 ident: B68 article-title: Infections of Helicobacter spp. in the biliary system are associated with biliary tract cancer: a meta-analysis publication-title: Eur J Gastroenterol Hepatol doi: 10.1097/MEG.0b013e32835c0362 – volume: 26 start-page: e12786 year: 2021 ident: B69 article-title: Helicobacter pylori infection is associated with the co-occurrence of bacteria in the oral cavity and the gastric mucosa publication-title: Helicobacter doi: 10.1111/hel.12786 |
| SSID | ssj0000650103 |
| Score | 2.3787997 |
| SecondaryResourceType | review_article |
| Snippet | Biliary tract cancers (BTCs), a group of rare aggressive malignancies, posed significant clinical challenges due to late diagnosis and limited therapies. While... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database |
| StartPage | 1585923 |
| SubjectTerms | bacterial translocation biliary tract cancer mechanisms oncogenic bacteria Oncology oral microbiota |
| Title | Oral microbiota and biliary tract cancers: unveiling hidden mechanistic links |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/40567604 https://www.proquest.com/docview/3224260646 https://pubmed.ncbi.nlm.nih.gov/PMC12187648 https://doaj.org/article/d6071073973c45f4a5c84615d66cae04 |
| Volume | 15 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NS8MwFA_iQbyI384vIngSqm1N08SbinMI04uD3UKWD9zBTLZO8L_3vaYbmwhevPTQJjT8Xpr3e30vvxByDqzCW-lcAguwS1ghi0SnRiSpkV5aIbitf2V3n3mnx576RX_hqC-sCYvywBG4K4sCaJhOKq8NKzzThQGXmRWWc6NdVAIFn7cQTMU1uMADDGIaE6IweeVHARUL8-IyA4Ys8-slR1Tr9f9GMn_WSi44n_Ym2WhYI72No90iKy5sk7VukxffId0X6ETfh1FVqdJUB0ux7FWPv2iFG6GoQfOOJzd0Gj7dEDeh0zeUDwn03eHu31qwmdb53F3Saz-83neS5qCExLA8rRIIOZxnJh8IaaXXsIhZ6G956UzGIJ7IvZaCSwlfN9PQmDvjDVA3410pc3D4e2Q1jII7IJSZ1Je8HMCn7ZnwEH14oUWtClhqmactcjFDTX1EPQwFcQRCrBBihRCrBuIWuUNc5w1Ryrq-AQZWjYHVXwZukbOZVRRMfcxn6OBG04mCtQj19TnjLbIfrTR_FfBQXnLsLZbstzSW5Sdh-FbLa2fAekrOxOF_jP6IrCMiWFyWZcdktRpP3QnQmGpwWs9YuD72s2_VWfAV |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Oral+microbiota+and+biliary+tract+cancers%3A+unveiling+hidden+mechanistic+links&rft.jtitle=Frontiers+in+oncology&rft.au=Zhang%2C+Yuhan&rft.au=Zhang%2C+Shu&rft.date=2025-06-11&rft.issn=2234-943X&rft.eissn=2234-943X&rft.volume=15&rft.spage=1585923&rft_id=info:doi/10.3389%2Ffonc.2025.1585923&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2234-943X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2234-943X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2234-943X&client=summon |