Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma - Becker, C. M.; Oberoi, R. K.; McFarren, S. J.; Muldoon, D. M.; Pafundi, D. H.; Pokorny, J. L.; Brinkmann, D. H.; Ohlfest, J. R.; Sarkaria, J. N.; Largaespada, D. A.; Elmquist, W. F. (Neuro-oncology (Charlottesville, Va.), 2015)
Keywords: Animals; Antineoplastic Agents - pharmacokinetics; ATP Binding Cassette Transporter, Sub-Family G, Member 2; ATP-Binding Cassette Transporters - antagonists & inhibitors; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette, Sub-Family B, Member 1 - genetics; Basic and Translational Investigations; Blood-Brain Barrier - metabolism; Brain - drug effects; Brain Neoplasms - metabolism; Brain Neoplasms - prevention & control; Bridged Bicyclo Compounds, Heterocyclic - pharmacokinetics; Drug Delivery Systems; Glioblastoma - metabolism; Glioblastoma - prevention & control; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphatidylinositol 3-Kinase - antagonists & inhibitors; Pyrimidines - pharmacokinetics; Thiophenes - pharmacokinetics; TOR Serine-Threonine Kinases - antagonists & inhibitors; blood-brain barrier; efflux transport; molecularly targeted agents; p-glycoprotein; brain tumors