Endothelial Glycocalyx in the Peripheral Capillaries is Injured Under Oxaliplatin-Induced Neuropathy

• Published in: The journal of pain Vol. 25; no. 6; p. 104462
• Main Authors: Kuroda, Takahiro, Suzuki, Akio, Okada, Hideshi, Shimizu, Masayoshi, Watanabe, Daichi, Suzuki, Keiko, Mori, Kosuke, Ohmura, Kazufumi, Niwa, Ayumi, Imaizumi, Yuko, Matsuo, Mikiko, Ichihashi, Koki, Okubo, Takafumi, Taniguchi, Toshiaki, Kanayma, Tomohiro, Kobayashi, Ryo, Sugie, Shigeyuki, Hara, Akira, Tomita, Hiroyuki
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2024
• Subjects: Animals; Antineoplastic Agents - pharmacology; Capillaries - drug effects; Capillaries - pathology; Capillary Permeability - drug effects; Capillary Permeability - physiology; Disease Models, Animal; Endothelial glycocalyx; Glycocalyx - drug effects; Glycocalyx - metabolism; Glycocalyx - pathology; Hyperalgesia - chemically induced; Hyperalgesia - pathology; Male; Mice; Mice, Inbred C57BL; Nafamostat mesilate; Neuropathy; Oxaliplatin; Oxaliplatin - toxicity; Peripheral capillary; Peripheral Nervous System Diseases - chemically induced; Peripheral Nervous System Diseases - pathology; Endothelial glycocalyx; Oxaliplatin; Neuropathy; Peripheral capillary; Nafamostat mesilate

Oxaliplatin, a platinum-based anticancer drug, is associated with peripheral neuropathy (oxaliplatin-induced peripheral neuropathy, OIPN), which can lead to worsening of quality of life and treatment interruption. The endothelial glycocalyx, a fragile carbohydrate-rich layer covering the luminal sur...