Modulation of Influenza A virus NS1 expression reveals prioritization of host response antagonism at single-cell resolution

• Published in: Frontiers in microbiology Vol. 14; p. 1267078
• Main Authors: Yang, Qing, Elz, Anna E, Panis, Maryline, Liu, Ting, Nilsson-Payant, Benjamin E, Blanco-Melo, Daniel
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 09.10.2023
• Subjects: immune antagonism; influenza; innate immune response; interferon; Microbiology; NS1; unfolded protein response; influenza; unfolded protein response; innate immune response; single cell transcriptomics; immune antagonism; interferon; NS1

Influenza A virus (IAV) is an important human respiratory pathogen that causes significant seasonal epidemics and potential devastating pandemics. As part of its life cycle, IAV encodes the multifunctional protein NS1, that, among many roles, prevents immune detection and limits interferon (IFN) pro...