Lactococcus lactis subsp. cremoris YRC3780 modifies function of mesenteric lymph node dendritic cells to modulate the balance of T cell differentiation inducing regulatory T cells

• Published in: Frontiers in immunology Vol. 15; p. 1395380
• Main Authors: Nakagawa, Ryogo, Gu, Wenting, Mizobuchi, Hibine, Kodera, Shuhei, Takano, Tomohiro, Wang, Yimei, Fujioka, Ikumi, Uchida, Kenji, Nakajima-Adachi, Haruyo, Hachimura, Satoshi
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08.07.2024
• Subjects: allergy; Animals; Cell Differentiation - immunology; Coculture Techniques; Cytokines - metabolism; dendritic cells; Dendritic Cells - immunology; Female; Immunology; intestine; lactic acid bacteria; Lactococcus lactis - immunology; Lymph Nodes - immunology; Lymphocyte Activation - immunology; Mesentery - immunology; Mice; Mice, Inbred BALB C; Mice, Transgenic; regulatory T cells; T-Lymphocytes, Regulatory - immunology; regulatory T cells; allergy; dendritic cells; intestine; lactic acid bacteria

The intestinal immune system plays a pivotal role in the induction of immune responses against food. In the case of T cell response, dendritic cells (DCs) are especially important. However, the regulation of immune responses to food by intestinal DCs has been poorly described. In this study, we anal...