Polymorphisms in the Wilms Tumor Gene Are Associated With Interindividual Variations in Rubella Virus–Specific Cellular Immunity After Measles-Mumps-Rubella II Vaccination

• Published in: The Journal of infectious diseases Vol. 217; no. 4; pp. 560 - 566
• Main Authors: Voigt, Emily A, Haralambieva, Iana H, Larrabee, Beth L, Kennedy, Richard B, Ovsyannikova, Inna G, Schaid, Daniel J, Poland, Gregory A
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 30.01.2018
• Subjects: Major and Brief Reports; genetic; SNP; genome-wide association study; measles-mumps-rubella vaccine; rubella; immunity; rubella virus; polymorphisms; IL-6

We conducted a genome-wide association study on 1843 subjects to identify genetic polymorphisms associated with cellular immunity after rubella vaccination. We identified single-nucleotide polymorphisms in the Wilms tumor gene WT1 that was significantly associated with interindividual differences in...