Polymorphisms in the Wilms Tumor Gene Are Associated With Interindividual Variations in Rubella Virus–Specific Cellular Immunity After Measles-Mumps-Rubella II Vaccination
We conducted a genome-wide association study on 1843 subjects to identify genetic polymorphisms associated with cellular immunity after rubella vaccination. We identified single-nucleotide polymorphisms in the Wilms tumor gene WT1 that was significantly associated with interindividual differences in...
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| Published in | The Journal of infectious diseases Vol. 217; no. 4; pp. 560 - 566 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Oxford University Press
30.01.2018
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| Abstract | We conducted a genome-wide association study on 1843 subjects to identify genetic polymorphisms associated with cellular immunity after rubella vaccination. We identified single-nucleotide polymorphisms in the Wilms tumor gene WT1 that was significantly associated with interindividual differences in subject rubella-specific interleukin 6 secretion.
Abstract
Rubella vaccination induces widely variable immune responses in vaccine recipients. While rubella vaccination is effective at inducing immunity to rubella infection in most subjects, up to 5% of individuals do not achieve or maintain long-term protective immunity. To expand upon our previous work identifying genetic polymorphisms that are associated with these interindividual differences in humoral immunity to rubella virus, we performed a genome-wide association study in a large cohort of 1843 subjects to discover single-nucleotide polymorphisms (SNPs) associated with rubella virus–specific cellular immune responses. We identified SNPs in the Wilms tumor protein gene (WT1) that were significantly associated (P < 5 × 10–8) with interindividual variations in rubella-specific interleukin 6 secretion from subjects’ peripheral blood mononuclear cells postvaccination. No SNPs were found to be significantly associated with variations in rubella-specific interferon-γ secretion. Our findings demonstrate that genetic polymorphisms in the WT1 gene in subjects of European ancestry are associated with interindividual differences in rubella virus–specific cellular immunity after measles-mumps-rubella II vaccination. |
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| AbstractList | We conducted a genome-wide association study on 1843 subjects to identify genetic polymorphisms associated with cellular immunity after rubella vaccination. We identified single-nucleotide polymorphisms in the Wilms tumor gene WT1 that was significantly associated with interindividual differences in subject rubella-specific interleukin 6 secretion.
Abstract
Rubella vaccination induces widely variable immune responses in vaccine recipients. While rubella vaccination is effective at inducing immunity to rubella infection in most subjects, up to 5% of individuals do not achieve or maintain long-term protective immunity. To expand upon our previous work identifying genetic polymorphisms that are associated with these interindividual differences in humoral immunity to rubella virus, we performed a genome-wide association study in a large cohort of 1843 subjects to discover single-nucleotide polymorphisms (SNPs) associated with rubella virus–specific cellular immune responses. We identified SNPs in the Wilms tumor protein gene (WT1) that were significantly associated (P < 5 × 10–8) with interindividual variations in rubella-specific interleukin 6 secretion from subjects’ peripheral blood mononuclear cells postvaccination. No SNPs were found to be significantly associated with variations in rubella-specific interferon-γ secretion. Our findings demonstrate that genetic polymorphisms in the WT1 gene in subjects of European ancestry are associated with interindividual differences in rubella virus–specific cellular immunity after measles-mumps-rubella II vaccination. Rubella vaccination induces widely variable immune responses in vaccine recipients. While rubella vaccination is effective at inducing immunity to rubella infection in most subjects, up to 5% of individuals do not achieve or maintain long-term protective immunity. To expand upon our previous work identifying genetic polymorphisms that are associated with these interindividual differences in humoral immunity to rubella virus, we performed a genome-wide association study in a large cohort of 1843 subjects to discover single-nucleotide polymorphisms (SNPs) associated with rubella virus-specific cellular immune responses. We identified SNPs in the Wilms tumor protein gene (WT1) that were significantly associated (P < 5 × 10-8) with interindividual variations in rubella-specific interleukin 6 secretion from subjects' peripheral blood mononuclear cells postvaccination. No SNPs were found to be significantly associated with variations in rubella-specific interferon-γ secretion. Our findings demonstrate that genetic polymorphisms in the WT1 gene in subjects of European ancestry are associated with interindividual differences in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination.Rubella vaccination induces widely variable immune responses in vaccine recipients. While rubella vaccination is effective at inducing immunity to rubella infection in most subjects, up to 5% of individuals do not achieve or maintain long-term protective immunity. To expand upon our previous work identifying genetic polymorphisms that are associated with these interindividual differences in humoral immunity to rubella virus, we performed a genome-wide association study in a large cohort of 1843 subjects to discover single-nucleotide polymorphisms (SNPs) associated with rubella virus-specific cellular immune responses. We identified SNPs in the Wilms tumor protein gene (WT1) that were significantly associated (P < 5 × 10-8) with interindividual variations in rubella-specific interleukin 6 secretion from subjects' peripheral blood mononuclear cells postvaccination. No SNPs were found to be significantly associated with variations in rubella-specific interferon-γ secretion. Our findings demonstrate that genetic polymorphisms in the WT1 gene in subjects of European ancestry are associated with interindividual differences in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination. Rubella vaccination induces widely variable immune responses in vaccine recipients. While rubella vaccination is effective at inducing immunity to rubella infection in most subjects, up to 5% of individuals do not achieve or maintain long-term protective immunity. To expand upon our previous work identifying genetic polymorphisms that are associated with these interindividual differences in humoral immunity to rubella virus, we performed a genome-wide association study in a large cohort of 1843 subjects to discover single-nucleotide polymorphisms (SNPs) associated with rubella virus-specific cellular immune responses. We identified SNPs in the Wilms tumor protein gene (WT1) that were significantly associated (P < 5 × 10-8) with interindividual variations in rubella-specific interleukin 6 secretion from subjects' peripheral blood mononuclear cells postvaccination. No SNPs were found to be significantly associated with variations in rubella-specific interferon-γ secretion. Our findings demonstrate that genetic polymorphisms in the WT1 gene in subjects of European ancestry are associated with interindividual differences in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination. We conducted a genome-wide association study on 1843 subjects to identify genetic polymorphisms associated with cellular immunity after rubella vaccination. We identified single-nucleotide polymorphisms in the Wilms tumor gene WT1 that was significantly associated with interindividual differences in subject rubella-specific interleukin 6 secretion. Rubella vaccination induces widely variable immune responses in vaccine recipients. While rubella vaccination is effective at inducing immunity to rubella infection in most subjects, up to 5% of individuals do not achieve or maintain long-term protective immunity. To expand upon our previous work identifying genetic polymorphisms that are associated with these interindividual differences in humoral immunity to rubella virus, we performed a genome-wide association study in a large cohort of 1843 subjects to discover single-nucleotide polymorphisms (SNPs) associated with rubella virus–specific cellular immune responses. We identified SNPs in the Wilms tumor protein gene ( WT1 ) that were significantly associated ( P < 5 × 10 –8 ) with interindividual variations in rubella-specific interleukin 6 secretion from subjects’ peripheral blood mononuclear cells postvaccination. No SNPs were found to be significantly associated with variations in rubella-specific interferon-γ secretion. Our findings demonstrate that genetic polymorphisms in the WT1 gene in subjects of European ancestry are associated with interindividual differences in rubella virus–specific cellular immunity after measles-mumps-rubella II vaccination. |
| Author | Haralambieva, Iana H Ovsyannikova, Inna G Voigt, Emily A Poland, Gregory A Kennedy, Richard B Schaid, Daniel J Larrabee, Beth L |
| AuthorAffiliation | 2 Mayo Clinic Division of Biostatistics, Mayo Clinic, Rochester, Minnesota 1 Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester |
| AuthorAffiliation_xml | – name: 2 Mayo Clinic Division of Biostatistics, Mayo Clinic, Rochester, Minnesota – name: 1 Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester |
| Author_xml | – sequence: 1 givenname: Emily A surname: Voigt fullname: Voigt, Emily A organization: Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester – sequence: 2 givenname: Iana H surname: Haralambieva fullname: Haralambieva, Iana H organization: Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester – sequence: 3 givenname: Beth L surname: Larrabee fullname: Larrabee, Beth L organization: Mayo Clinic Division of Biostatistics, Mayo Clinic, Rochester, Minnesota – sequence: 4 givenname: Richard B surname: Kennedy fullname: Kennedy, Richard B organization: Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester – sequence: 5 givenname: Inna G surname: Ovsyannikova fullname: Ovsyannikova, Inna G organization: Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester – sequence: 6 givenname: Daniel J surname: Schaid fullname: Schaid, Daniel J organization: Mayo Clinic Division of Biostatistics, Mayo Clinic, Rochester, Minnesota – sequence: 7 givenname: Gregory A surname: Poland fullname: Poland, Gregory A email: poland.gregory@mayo.edu organization: Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester |
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| CitedBy_id | crossref_primary_10_3390_jcm9113561 crossref_primary_10_3389_fimmu_2019_00180 crossref_primary_10_3389_fgene_2023_1164274 crossref_primary_10_1016_S0140_6736_21_02691_X crossref_primary_10_1111_aji_13294 crossref_primary_10_1016_j_ijbiomac_2024_138671 crossref_primary_10_3389_fmed_2022_802312 crossref_primary_10_1016_j_vaccine_2023_02_009 crossref_primary_10_1038_s41598_024_59259_1 crossref_primary_10_1186_s12711_021_00614_5 crossref_primary_10_1016_j_vaccine_2023_09_001 crossref_primary_10_7774_cevr_2024_13_2_105 crossref_primary_10_1016_j_vaccine_2019_05_049 crossref_primary_10_1016_j_clim_2021_108912 crossref_primary_10_1016_j_exger_2019_110632 |
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| Copyright | The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2017 The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. |
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| Keywords | genetic SNP genome-wide association study measles-mumps-rubella vaccine rubella immunity rubella virus polymorphisms IL-6 |
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| Snippet | We conducted a genome-wide association study on 1843 subjects to identify genetic polymorphisms associated with cellular immunity after rubella vaccination. We... Rubella vaccination induces widely variable immune responses in vaccine recipients. While rubella vaccination is effective at inducing immunity to rubella... |
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| Title | Polymorphisms in the Wilms Tumor Gene Are Associated With Interindividual Variations in Rubella Virus–Specific Cellular Immunity After Measles-Mumps-Rubella II Vaccination |
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