In vivo screening for toxicity-modulating drug interactions identifies antagonism that protects against ototoxicity in zebrafish

• Published in: Frontiers in pharmacology Vol. 15; p. 1363545
• Main Authors: Bustad, Ethan, Mudrock, Emma, Nilles, Elizabeth M, Mcquate, Andrea, Bergado, Monica, Gu, Alden, Galitan, Louie, Gleason, Natalie, Ou, Henry C, Raible, David W, Hernandez, Rafael E, Ma, Shuyi
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 07.03.2024
• Subjects: aminoglycosides; drug-drug interactions; otoprotection; ototoxicity; Pharmacology; toxicity protection; zebrafish; drug-drug interactions; macrolides; ototoxicity; otoprotection; toxicity protection; aminoglycosides; zebrafish

Ototoxicity is a debilitating side effect of over 150 medications with diverse mechanisms of action, many of which could be taken concurrently to treat multiple conditions. Approaches for preclinical evaluation of drug-drug interactions that might impact ototoxicity would facilitate design of safer...