Lipid peroxidation: Mechanisms, inhibition, and biological effects
In the last 50 years, lipid peroxidation has been the subject of extensive studies from the viewpoints of mechanisms, dynamics, product analysis, involvement in diseases, inhibition, and biological signaling. Lipids are oxidized by three distinct mechanisms; enzymatic oxidation, non-enzymatic, free...
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Published in | Biochemical and biophysical research communications Vol. 338; no. 1; pp. 668 - 676 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
09.12.2005
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Subjects | |
Online Access | Get full text |
ISSN | 0006-291X 1090-2104 |
DOI | 10.1016/j.bbrc.2005.08.072 |
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Abstract | In the last 50 years, lipid peroxidation has been the subject of extensive studies from the viewpoints of mechanisms, dynamics, product analysis, involvement in diseases, inhibition, and biological signaling. Lipids are oxidized by three distinct mechanisms; enzymatic oxidation, non-enzymatic, free radical-mediated oxidation, and non-enzymatic, non-radical oxidation. Each oxidation mechanism yields specific products. The oxidation of linoleates and cholesterol is discussed in some detail. The relative susceptibilities of lipids to oxidation depend on the reaction milieu as well as their inherent structure. Lipid hydroperoxides are formed as the major primary products, however they are substrates for various enzymes and they also undergo various secondary reactions. Phospholipid hydroperoxides, for example, are reduced to the corresponding hydroxides by selenoproteins in vivo. Various kinds of antioxidants with different functions inhibit lipid peroxidation and the deleterious effects caused by the lipid peroxidation products. Furthermore, the biological role of lipid peroxidation products has recently received a great deal of attention, but its physiological significance must be demonstrated in future studies. |
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AbstractList | In the last 50 years, lipid peroxidation has been the subject of extensive studies from the viewpoints of mechanisms, dynamics, product analysis, involvement in diseases, inhibition, and biological signaling. Lipids are oxidized by three distinct mechanisms; enzymatic oxidation, non-enzymatic, free radical-mediated oxidation, and non-enzymatic, non-radical oxidation. Each oxidation mechanism yields specific products. The oxidation of linoleates and cholesterol is discussed in some detail. The relative susceptibilities of lipids to oxidation depend on the reaction milieu as well as their inherent structure. Lipid hydroperoxides are formed as the major primary products, however they are substrates for various enzymes and they also undergo various secondary reactions. Phospholipid hydroperoxides, for example, are reduced to the corresponding hydroxides by selenoproteins in vivo. Various kinds of antioxidants with different functions inhibit lipid peroxidation and the deleterious effects caused by the lipid peroxidation products. Furthermore, the biological role of lipid peroxidation products has recently received a great deal of attention, but its physiological significance must be demonstrated in future studies.In the last 50 years, lipid peroxidation has been the subject of extensive studies from the viewpoints of mechanisms, dynamics, product analysis, involvement in diseases, inhibition, and biological signaling. Lipids are oxidized by three distinct mechanisms; enzymatic oxidation, non-enzymatic, free radical-mediated oxidation, and non-enzymatic, non-radical oxidation. Each oxidation mechanism yields specific products. The oxidation of linoleates and cholesterol is discussed in some detail. The relative susceptibilities of lipids to oxidation depend on the reaction milieu as well as their inherent structure. Lipid hydroperoxides are formed as the major primary products, however they are substrates for various enzymes and they also undergo various secondary reactions. Phospholipid hydroperoxides, for example, are reduced to the corresponding hydroxides by selenoproteins in vivo. Various kinds of antioxidants with different functions inhibit lipid peroxidation and the deleterious effects caused by the lipid peroxidation products. Furthermore, the biological role of lipid peroxidation products has recently received a great deal of attention, but its physiological significance must be demonstrated in future studies. In the last 50 years, lipid peroxidation has been the subject of extensive studies from the viewpoints of mechanisms, dynamics, product analysis, involvement in diseases, inhibition, and biological signaling. Lipids are oxidized by three distinct mechanisms; enzymatic oxidation, non-enzymatic, free radical-mediated oxidation, and non-enzymatic, non-radical oxidation. Each oxidation mechanism yields specific products. The oxidation of linoleates and cholesterol is discussed in some detail. The relative susceptibilities of lipids to oxidation depend on the reaction milieu as well as their inherent structure. Lipid hydroperoxides are formed as the major primary products, however they are substrates for various enzymes and they also undergo various secondary reactions. Phospholipid hydroperoxides, for example, are reduced to the corresponding hydroxides by selenoproteins in vivo. Various kinds of antioxidants with different functions inhibit lipid peroxidation and the deleterious effects caused by the lipid peroxidation products. Furthermore, the biological role of lipid peroxidation products has recently received a great deal of attention, but its physiological significance must be demonstrated in future studies. |
Author | Noguchi, Noriko Niki, Etsuo Yoshida, Yasukazu Saito, Yoshiro |
Author_xml | – sequence: 1 givenname: Etsuo surname: Niki fullname: Niki, Etsuo email: etsuo-niki@aist.go.jp organization: Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Osaka 563-8577, Japan – sequence: 2 givenname: Yasukazu surname: Yoshida fullname: Yoshida, Yasukazu organization: Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Osaka 563-8577, Japan – sequence: 3 givenname: Yoshiro surname: Saito fullname: Saito, Yoshiro organization: Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Osaka 563-8577, Japan – sequence: 4 givenname: Noriko surname: Noguchi fullname: Noguchi, Noriko organization: Faculty of Engineering, Department of Environmental Systems Science, Doshisha University, Kyoto 610-0321, Japan |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16126168$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Animals Antioxidant Cholesterol HODE Humans Linoleic acid Lipid peroxidation Lipid Peroxidation - physiology Lipid Peroxides - antagonists & inhibitors Lipid Peroxides - chemistry Lipid Peroxides - metabolism Lipid Peroxides - physiology Oxysterols Vitamin E |
Title | Lipid peroxidation: Mechanisms, inhibition, and biological effects |
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