Lipid peroxidation: Mechanisms, inhibition, and biological effects

In the last 50 years, lipid peroxidation has been the subject of extensive studies from the viewpoints of mechanisms, dynamics, product analysis, involvement in diseases, inhibition, and biological signaling. Lipids are oxidized by three distinct mechanisms; enzymatic oxidation, non-enzymatic, free...

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Published inBiochemical and biophysical research communications Vol. 338; no. 1; pp. 668 - 676
Main Authors Niki, Etsuo, Yoshida, Yasukazu, Saito, Yoshiro, Noguchi, Noriko
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 09.12.2005
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Online AccessGet full text
ISSN0006-291X
1090-2104
DOI10.1016/j.bbrc.2005.08.072

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Abstract In the last 50 years, lipid peroxidation has been the subject of extensive studies from the viewpoints of mechanisms, dynamics, product analysis, involvement in diseases, inhibition, and biological signaling. Lipids are oxidized by three distinct mechanisms; enzymatic oxidation, non-enzymatic, free radical-mediated oxidation, and non-enzymatic, non-radical oxidation. Each oxidation mechanism yields specific products. The oxidation of linoleates and cholesterol is discussed in some detail. The relative susceptibilities of lipids to oxidation depend on the reaction milieu as well as their inherent structure. Lipid hydroperoxides are formed as the major primary products, however they are substrates for various enzymes and they also undergo various secondary reactions. Phospholipid hydroperoxides, for example, are reduced to the corresponding hydroxides by selenoproteins in vivo. Various kinds of antioxidants with different functions inhibit lipid peroxidation and the deleterious effects caused by the lipid peroxidation products. Furthermore, the biological role of lipid peroxidation products has recently received a great deal of attention, but its physiological significance must be demonstrated in future studies.
AbstractList In the last 50 years, lipid peroxidation has been the subject of extensive studies from the viewpoints of mechanisms, dynamics, product analysis, involvement in diseases, inhibition, and biological signaling. Lipids are oxidized by three distinct mechanisms; enzymatic oxidation, non-enzymatic, free radical-mediated oxidation, and non-enzymatic, non-radical oxidation. Each oxidation mechanism yields specific products. The oxidation of linoleates and cholesterol is discussed in some detail. The relative susceptibilities of lipids to oxidation depend on the reaction milieu as well as their inherent structure. Lipid hydroperoxides are formed as the major primary products, however they are substrates for various enzymes and they also undergo various secondary reactions. Phospholipid hydroperoxides, for example, are reduced to the corresponding hydroxides by selenoproteins in vivo. Various kinds of antioxidants with different functions inhibit lipid peroxidation and the deleterious effects caused by the lipid peroxidation products. Furthermore, the biological role of lipid peroxidation products has recently received a great deal of attention, but its physiological significance must be demonstrated in future studies.In the last 50 years, lipid peroxidation has been the subject of extensive studies from the viewpoints of mechanisms, dynamics, product analysis, involvement in diseases, inhibition, and biological signaling. Lipids are oxidized by three distinct mechanisms; enzymatic oxidation, non-enzymatic, free radical-mediated oxidation, and non-enzymatic, non-radical oxidation. Each oxidation mechanism yields specific products. The oxidation of linoleates and cholesterol is discussed in some detail. The relative susceptibilities of lipids to oxidation depend on the reaction milieu as well as their inherent structure. Lipid hydroperoxides are formed as the major primary products, however they are substrates for various enzymes and they also undergo various secondary reactions. Phospholipid hydroperoxides, for example, are reduced to the corresponding hydroxides by selenoproteins in vivo. Various kinds of antioxidants with different functions inhibit lipid peroxidation and the deleterious effects caused by the lipid peroxidation products. Furthermore, the biological role of lipid peroxidation products has recently received a great deal of attention, but its physiological significance must be demonstrated in future studies.
In the last 50 years, lipid peroxidation has been the subject of extensive studies from the viewpoints of mechanisms, dynamics, product analysis, involvement in diseases, inhibition, and biological signaling. Lipids are oxidized by three distinct mechanisms; enzymatic oxidation, non-enzymatic, free radical-mediated oxidation, and non-enzymatic, non-radical oxidation. Each oxidation mechanism yields specific products. The oxidation of linoleates and cholesterol is discussed in some detail. The relative susceptibilities of lipids to oxidation depend on the reaction milieu as well as their inherent structure. Lipid hydroperoxides are formed as the major primary products, however they are substrates for various enzymes and they also undergo various secondary reactions. Phospholipid hydroperoxides, for example, are reduced to the corresponding hydroxides by selenoproteins in vivo. Various kinds of antioxidants with different functions inhibit lipid peroxidation and the deleterious effects caused by the lipid peroxidation products. Furthermore, the biological role of lipid peroxidation products has recently received a great deal of attention, but its physiological significance must be demonstrated in future studies.
Author Noguchi, Noriko
Niki, Etsuo
Yoshida, Yasukazu
Saito, Yoshiro
Author_xml – sequence: 1
  givenname: Etsuo
  surname: Niki
  fullname: Niki, Etsuo
  email: etsuo-niki@aist.go.jp
  organization: Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Osaka 563-8577, Japan
– sequence: 2
  givenname: Yasukazu
  surname: Yoshida
  fullname: Yoshida, Yasukazu
  organization: Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Osaka 563-8577, Japan
– sequence: 3
  givenname: Yoshiro
  surname: Saito
  fullname: Saito, Yoshiro
  organization: Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Osaka 563-8577, Japan
– sequence: 4
  givenname: Noriko
  surname: Noguchi
  fullname: Noguchi, Noriko
  organization: Faculty of Engineering, Department of Environmental Systems Science, Doshisha University, Kyoto 610-0321, Japan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/16126168$$D View this record in MEDLINE/PubMed
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Snippet In the last 50 years, lipid peroxidation has been the subject of extensive studies from the viewpoints of mechanisms, dynamics, product analysis, involvement...
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SubjectTerms Animals
Antioxidant
Cholesterol
HODE
Humans
Linoleic acid
Lipid peroxidation
Lipid Peroxidation - physiology
Lipid Peroxides - antagonists & inhibitors
Lipid Peroxides - chemistry
Lipid Peroxides - metabolism
Lipid Peroxides - physiology
Oxysterols
Vitamin E
Title Lipid peroxidation: Mechanisms, inhibition, and biological effects
URI https://dx.doi.org/10.1016/j.bbrc.2005.08.072
https://www.ncbi.nlm.nih.gov/pubmed/16126168
https://www.proquest.com/docview/68754571
Volume 338
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