Degradation of ZIF-8 in phosphate buffered saline media

• Published in: CrystEngComm Vol. 21; no. 31; pp. 4538 - 4544
• Main Authors: Velsquez-Hernndez, Miriam de J, Ricco, Raffaele, Carraro, Francesco, Limpoco, F. Ted, Linares-Moreau, Mercedes, Leitner, Erich, Wiltsche, Helmar, Rattenberger, Johannes, Schrttner, Hartmuth, Frhwirt, Philipp, Stadler, Eduard M, Gescheidt, Georg, Amenitsch, Heinz, Doonan, Christian J, Falcaro, Paolo
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 2019
• Subjects: Atomic force microscopy; Buffer solutions; Drug delivery systems; Metal-organic frameworks; NMR; Nuclear magnetic resonance; Organic chemistry; Small angle X ray scattering; X ray powder diffraction; Zeolites
• ISSN: 1466-8033; 1466-8033
• DOI: 10.1039/c9ce00757a

Understanding the stability of zeolitic imidazolate framework-8 (ZIF-8) under physiological conditions is critical in biotechnology and biomedicine for biosensing, biocatalysis, and drug delivery. The use of ZIF-8 has shown that this metal organic framework (MOF) and its derived bio-composites can degrade in presence of buffer solutions. Here we present an in-depth analysis of the structural and chemical changes of pure ZIF-8 particles exposed to phosphate buffered saline (PBS) media. Two different particle sizes (2 m and 250 nm) were selected and the decomposition operated by 10 mM PBS (aka 1X) was studied using powder X-ray diffraction (PXRD), Fourier transformed infrared spectroscopy (FTIR), time resolved atomic force microscopy (AFM), in situ small angle X-ray scattering (SAXS), and 31 P NMR. Understanding the stability of zeolitic imidazolate framework-8 (ZIF-8) under physiological conditions is critical in biotechnology and biomedicine for biosensing, biocatalysis, and drug delivery.