Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/β-Catenin Signaling

• Published in: Journal of the American Society of Nephrology Vol. 24; no. 5; pp. 771 - 785
• Main Authors: Zhou, Lili, Li, Yingjian, Zhou, Dong, Tan, Roderick J., Liu, Youhua
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society of Nephrology 01.05.2013
• Subjects: Animals; Basic Research; beta Catenin - antagonists & inhibitors; beta Catenin - physiology; Biological and medical sciences; Cells, Cultured; Fibrosis; Glucuronidase - physiology; Humans; Kidney - pathology; Male; Medical sciences; Mice; Mice, Inbred BALB C; Nephrology. Urinary tract diseases; Renal Insufficiency, Chronic - etiology; Signal Transduction - physiology; Transcription, Genetic; Transforming Growth Factor beta1 - physiology; Wnt Signaling Pathway - physiology; Nephrology; Urinary system; Wnt/β-catenin signaling pathway; Injury; Lesion; Kidney; Urology

Aging is an independent risk factor for CKD, but the molecular mechanisms that link aging and CKD are not well understood. The antiaging protein Klotho may be an endogenous antagonist of Wnt/β-catenin signaling, which promotes fibrogenesis, suggesting that loss of Klotho may contribute to CKD throug...