Mapping the interaction sites of human and avian influenza A viruses and complement factor H

• Published in: Frontiers in immunology Vol. 15; p. 1352022
• Main Authors: Rabeeah, Iman, Billington, Elizabeth, Nal, Béatrice, Sadeyen, Jean-Remy, Pathan, Ansar A, Iqbal, Munir, Temperton, Nigel J, Zipfel, Peter F, Skerka, Christine, Kishore, Uday, Shelton, Holly
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 18.04.2024
• Subjects: Animals; avian influenza; Binding Sites; Birds - virology; complement; Complement Factor H - immunology; Complement Factor H - metabolism; factor H; Hemagglutinin Glycoproteins, Influenza Virus - immunology; Hemagglutinin Glycoproteins, Influenza Virus - metabolism; Host-Pathogen Interactions - immunology; human influenza; Humans; Immunology; influenza A virus; Influenza A virus - immunology; Influenza A virus - physiology; Influenza A Virus, H3N2 Subtype - immunology; Influenza A Virus, H9N2 Subtype - immunology; Influenza in Birds - immunology; Influenza in Birds - metabolism; Influenza in Birds - virology; Influenza, Human - immunology; Influenza, Human - metabolism; Influenza, Human - virology; Protein Binding; pseudotype; entry inhibitor; human influenza; avian influenza; complement; factor H; pseudotype; influenza A virus

The complement system is an innate immune mechanism against microbial infections. It involves a cascade of effector molecules that is activated via classical, lectin and alternative pathways. Consequently, many pathogens bind to or incorporate in their structures host negative regulators of the comp...