Extended Production of Cortical Interneurons into the Third Trimester of Human Gestation

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 26; no. 5; pp. 2242 - 2256
• Main Authors: Arshad, Arslan, Vose, Linnea R., Vinukonda, Govindaiah, Hu, Furong, Yoshikawa, Kazuaki, Csiszar, Anna, Brumberg, Joshua C., Ballabh, Praveen
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.05.2016
• Subjects: Brain - embryology; Brain - metabolism; Brain - physiology; Cell Count; Cerebral Cortex - embryology; Cerebral Cortex - metabolism; Cerebral Cortex - physiology; Female; Fetal Development; GABAergic Neurons - metabolism; GABAergic Neurons - physiology; Gestational Age; Homeodomain Proteins - metabolism; Humans; Interneurons - metabolism; Interneurons - physiology; Lateral Ventricles - embryology; Lateral Ventricles - metabolism; Lateral Ventricles - physiology; Male; Median Eminence - embryology; Median Eminence - physiology; Neural Stem Cells - metabolism; Neural Stem Cells - physiology; Neurogenesis; Nuclear Proteins - metabolism; Pregnancy; Pregnancy Trimester, Third; Thyroid Nuclear Factor 1; Transcription Factors - metabolism; Sox2; subventricular zone; Dlx2; ganglionic eminence; GABAergic; interneuron; Nkx2.1

In humans, the developmental origins of interneurons in the third trimester of pregnancy and the timing of completion of interneuron neurogenesis have remained unknown. Here, we show that the total and cycling Nkx2.1(+)and Dlx2(+)interneuron progenitors as well as Sox2(+)precursor cells were higher...