Purification and characterization of a uterine phospholipase inhibitor that loses activity after labor onset in women

• Published in: American journal of obstetrics and gynecology Vol. 160; no. 3; p. 602
• Main Authors: Wilson, T, Liggins, G C, Joe, L
• Format: Journal Article
• Language: English
• Published: United States 01.03.1989
• Subjects: Chorion - metabolism; Female; Humans; Labor, Obstetric - metabolism; Molecular Weight; Phospholipases - antagonists & inhibitors; Pregnancy; Pregnancy Proteins - isolation & purification; Pregnancy Proteins - metabolism; Pregnancy Proteins - physiology; Uterus - enzymology

Gravidin, a protein that inhibits release of arachidonic acid from human decidual cells, was purified from amniotic fluid. The protein has a molecular weight of 58 to 60 kilodaltons, an isoelectric point of 8.4, and physical characteristics that are indistinguishable from those of inhibitor II previ...