Bedside Monitoring to Adjust Antiplatelet Therapy for Coronary Stenting

• Published in: The New England journal of medicine Vol. 367; no. 22; pp. 2100 - 2109
• Main Authors: Collet, Jean-Philippe, Cuisset, Thomas, Rangé, Grégoire, Cayla, Guillaume, Elhadad, Simon, Pouillot, Christophe, Henry, Patrick, Motreff, Pascal, Carrié, Didier, Boueri, Ziad, Belle, Loic, Van Belle, Eric, Rousseau, Hélène, Aubry, Pierre, Monségu, Jacques, Sabouret, Pierre, O'Connor, Stephen A, Abtan, Jérémie, Kerneis, Mathieu, Saint-Etienne, Christophe, Barthélémy, Olivier, Beygui, Farzin, Silvain, Johanne, Vicaut, Eric, Montalescot, Gilles
• Format: Journal Article
• Language: English
• Published: Waltham, MA Massachusetts Medical Society 29.11.2012
• Subjects: Acute coronary syndromes; Aged; Antiplatelet therapy; Aspirin; Aspirin - administration & dosage; Biological and medical sciences; Cardiology. Vascular system; Catheterization; Cerebral infarction; Clinical trials; Clopidogrel; Coronary Disease - mortality; Coronary Disease - therapy; Coronary heart disease; Coronary Thrombosis; Diseases of the cardiovascular system; Drug dosages; Drug Monitoring - methods; Drug therapy; Female; General aspects; Heart; Heart attacks; Humans; Implants; Male; Medical sciences; Middle Aged; Myocardial infarction; Myocardial Infarction - epidemiology; Patients; Piperazines - administration & dosage; Platelet Aggregation Inhibitors - administration & dosage; Platelets; Point-of-Care Systems; Prasugrel Hydrochloride; Pyridines - administration & dosage; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Retreatment; Stents; Stents - adverse effects; Stroke; Thiophenes - administration & dosage; Thrombosis; Ticlopidine - administration & dosage; Ticlopidine - analogs & derivatives; France; Bed; Endoprosthesis; Point-of-care testing; Angioplasty; Coronary artery; Instrumentation therapy; Cardiovascular disease; Patient; Coronary heart disease; Stent; Antiplatelet agent; Medicine; Chemotherapy; Treatment; Surveillance; Point of care testing

In this trial, bedside platelet-function monitoring to adjust antiplatelet therapy after coronary stent implantation did not reduce the rate of subsequent cardiovascular events, a finding that calls into question the clinical value of this type of testing. Clopidogrel and aspirin play a central role...