A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic options

Despite undeniable advances in modern medicine, lung cancer still has high morbidity and mortality rates. Lung cancer is preventable and treatable, and it is important to identify new risk factors for lung cancer, especially those that can be treated or reversed. Obstructive sleep apnea (OSA) is a v...

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Published inFrontiers in immunology Vol. 15; p. 1374236
Main Authors Yuan, Fang, Hu, Yanxia, Xu, Fei, Feng, Xujun
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 28.03.2024
Subjects
epidemiology
Immunology
intermittent hypoxia
lung cancer
obstructive sleep apnea
tumor associated macrophages
lung cancer
obstructive sleep apnea
epidemiology
tumor associated macrophages
intermittent hypoxia
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Abstract Despite undeniable advances in modern medicine, lung cancer still has high morbidity and mortality rates. Lung cancer is preventable and treatable, and it is important to identify new risk factors for lung cancer, especially those that can be treated or reversed. Obstructive sleep apnea (OSA) is a very common sleep-breathing disorder that is grossly underestimated in clinical practice. It can cause, exacerbate, and worsen adverse outcomes, including death and various diseases, but its relationship with lung cancer is unclear. A possible causal relationship between OSA and the onset and progression of lung cancer has been established biologically. The pathophysiological processes associated with OSA, such as sleep fragmentation, intermittent hypoxia, and increased sympathetic nervous excitation, may affect normal neuroendocrine regulation, impair immune function (especially innate and cellular immunity), and ultimately contribute to the occurrence of lung cancer, accelerate progression, and induce treatment resistance. OSA may be a contributor to but a preventable cause of the progression of lung cancer. However, whether this effect exists independently of other risk factors is unclear. Therefore, by reviewing the literature on the epidemiology, pathogenesis, and treatment of lung cancer and OSA, we hope to understand the relationships between the two and promote the interdisciplinary exchange of ideas between basic medicine, clinical medicine, respiratory medicine, sleep medicine, and oncology.
AbstractList Despite undeniable advances in modern medicine, lung cancer still has high morbidity and mortality rates. Lung cancer is preventable and treatable, and it is important to identify new risk factors for lung cancer, especially those that can be treated or reversed. Obstructive sleep apnea (OSA) is a very common sleep-breathing disorder that is grossly underestimated in clinical practice. It can cause, exacerbate, and worsen adverse outcomes, including death and various diseases, but its relationship with lung cancer is unclear. A possible causal relationship between OSA and the onset and progression of lung cancer has been established biologically. The pathophysiological processes associated with OSA, such as sleep fragmentation, intermittent hypoxia, and increased sympathetic nervous excitation, may affect normal neuroendocrine regulation, impair immune function (especially innate and cellular immunity), and ultimately contribute to the occurrence of lung cancer, accelerate progression, and induce treatment resistance. OSA may be a contributor to but a preventable cause of the progression of lung cancer. However, whether this effect exists independently of other risk factors is unclear. Therefore, by reviewing the literature on the epidemiology, pathogenesis, and treatment of lung cancer and OSA, we hope to understand the relationships between the two and promote the interdisciplinary exchange of ideas between basic medicine, clinical medicine, respiratory medicine, sleep medicine, and oncology.
Author Hu, Yanxia
Feng, Xujun
Yuan, Fang
Xu, Fei
AuthorAffiliation 2 Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University , Nanchang , China
3 Department of Respiratory and Critical Care Medicine, Sleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University , Chengdu , China
1 Department of Respiratory, The First Hospital of Jiujiang City , Jiujiang , China
AuthorAffiliation_xml – name: 3 Department of Respiratory and Critical Care Medicine, Sleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University , Chengdu , China
– name: 1 Department of Respiratory, The First Hospital of Jiujiang City , Jiujiang , China
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  surname: Yuan
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– sequence: 3
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  organization: Department of Respiratory and Critical Care Medicine, Sleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University, Chengdu, China
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Cites_doi 10.1158/1055-9965.EPI-20-0975
10.1007/s11325-015-1295-7
10.1016/S0022-5347(17)51493-7
10.1038/srep44693
10.1111/j.1463-1326.2009.01045.x
10.1001/jamaoncol.2022.5389
10.1200/JCO.23.01060
10.1183/16000617.0256-2021
10.1152/physrev.00043.2008
10.1016/j.chest.2016.08.1438
10.1007/s12094-018-1955-8
10.1056/NEJM200005113421901
10.3389/fimmu.2016.00550
10.1164/rccm.201310-1830OC
10.1080/13510002.2023.2279813
10.1093/sleep/zsab030
10.1038/s41571-023-00733-6
10.1016/j.intimp.2023.110652
10.1002/alr.23079
10.1016/j.chest.2023.04.043
10.3322/caac.21785
10.3760/cma.j.issn.0253-3766.2018.01.002
10.1016/j.sleep.2023.01.020
10.3390/cancers15184648
10.2147/IJN.S264498
10.1038/s41568-019-0179-8
10.5664/jcsm.7812
10.3389/fonc.2022.856121
10.5664/jcsm.9804
10.1016/j.jtho.2022.10.002
10.3322/caac.21660
10.1016/j.smrv.2016.07.002
10.5665/sleep.6004
10.1016/j.smrv.2016.12.003
10.1093/sleep/zsaa198
10.1371/journal.pone.0212930
10.1007/s00405-018-5219-6
10.1016/j.chest.2020.06.055
10.1183/23120541.00777-2023
10.1016/j.sleep.2020.02.009
10.7150/ijbs.70958
10.1016/j.cub.2020.06.081
10.1046/j.1440-1827.2002.01367.x
10.1016/j.sleep.2023.05.013
10.5664/jcsm.8432
10.1016/B978-0-444-53817-8.00003-7
10.1186/s13046-023-02753-7
10.18632/oncotarget.15372
10.3389/fonc.2023.1214279
10.1159/000486577
10.1093/sleep/zsw040
10.1038/s41571-023-00798-3
10.3390/cancers12092402
10.1038/s41598-021-94272-8
10.1016/j.semcancer.2023.01.006
10.1177/0194599819900487
10.5665/sleep.3574
10.1159/000492273
10.3389/fendo.2022.820939
10.1038/s41568-021-00413-6
10.3892/or.2020.7913
10.1016/j.sleep.2021.05.029
10.1016/j.lfs.2017.02.008
10.1016/j.cmet.2019.06.001
10.1016/j.canlet.2015.03.010
10.3389/fimmu.2023.1148061
10.21037/atm.2019.01.44
10.1016/j.it.2011.12.001
10.1097/GME.0000000000001526
10.18632/oncotarget.2785
10.3322/caac.21763
10.1016/j.sleep.2019.05.011
10.1183/13993003.01298-2018
10.5665/sleep.2374
10.7759/cureus.25230
10.1016/j.omtn.2020.12.023
10.1007/s11325-021-02458-1
10.1074/jbc.M407706200
10.2147/IJGM.S330681
10.1007/s11325-021-02369-1
10.1016/j.chest.2020.02.036
10.1038/s41598-020-58906-7
10.1016/j.chest.2023.06.012
10.1007/s10552-018-1073-5
10.1111/resp.13838
10.3389/fimmu.2016.00052
10.1007/s11596-019-2075-6
10.1016/j.bcp.2018.12.010
10.1186/s12943-022-01505-z
10.1183/13993003.00833-2017
10.1016/j.jtho.2021.09.009
10.1038/s41392-023-01496-3
10.1007/s11325-022-02750-8
10.1126/scitranslmed.aad7118
10.1093/eurheartj/ehy624
10.1186/s12931-021-01655-6
10.1016/j.apsb.2021.01.001
10.3389/fmed.2022.810907
10.1183/13993003.02456-2016
10.1513/AnnalsATS.202108-960OC
10.1186/s11658-022-00345-5
10.1016/j.semcancer.2022.11.006
10.1016/j.bbrc.2019.10.145
10.1158/0008-5472.CAN-13-3014
10.1016/j.biopha.2021.111450
10.1038/s41569-023-00846-6
10.1096/fj.202001247RR
10.1056/NEJMra1514296
10.1016/j.sleep.2023.10.034
10.1016/S0140-6736(22)01694-4
10.1002/ctm2.288
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Keywords lung cancer
obstructive sleep apnea
epidemiology
tumor associated macrophages
intermittent hypoxia
Language English
License Copyright © 2024 Yuan, Hu, Xu and Feng.
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Edited by: Reem Amr Assal, Heliopolis University for Sustainable Development, Egypt
Reviewed by: Anna Brzecka, Wroclaw Medical University, Poland
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References Bhaisare (B19) 2022; 145
Gharib (B106) 2014; 37
Khan (B88) 2023; 42
Qi (B101) 2023; 107
Cui (B58) 2023; 28
Penner (B111) 2019; 15
Megyesfalvi (B91) 2023; 73
Anderson (B49) 2020; 30
Peppard (B13) 2000; 34219
Vitale (B53) 2019; 301
Ruffell (B65) 2012; 33
Brenner (B32) 2019; 971
Almendros (B70) 2015; 361
Xie (B10) 2021; 138
Torres (B68) 2020; 27
Siegel (B4) 2023; 731
Liu (B42) 2019; 394
Jara (B26) 2020; 1624
Bardhan (B61) 2016; 7
Javaheri (B9) 2020; 1582
Li (B99) 2017; 8
Huang (B41) 2023; 89
Huang (B27) 2021; 443
Eckert (B39) 2018; 37
Cheng (B22) 2021; 84
Sillah (B34) 2018; 2910
Tauriello (B56) 2022; 22
Hao (B77) 2022; 27
Touitou (B38) 2017; 173
Heng (B74) 2019; 160
Wang (B66) 2021; 11
Lyons (B36) 2020; 257
Hernández-Jiménez (B57) 2017; 49
Zhang (B86) 2020; 15
Lee (B20) 2023; 274
Aini (B16) 2023; 103
Akbarpour (B55) 2017; 40
Zhao (B79) 2022; 18
Redline (B35) 2023; 208
Harada (B93) 2023; 20
Xue (B96) 2023; 14
Gozal (B25) 2016; 398
Du (B15) 2023; 112
Jackson (B17) 2011; 190
Wallace (B18) 2013; 362
Seijo (B30) 2019; 63
Adams (B45) 2023; 401
Gross (B64) 2022; 17
Gu (B75) 2021; 45
Nakamura (B43) 2002; 52
Chen (B29) 2018; 40
Gleeson (B2) 2022; 31
Cubillos-Zapata (B85) 2024; 10
Xie (B51) 2019; 276
Hakim (B54) 2014; 74
Guo (B47) 2019; 142
Skoulidis (B92) 2019; 19
Liu (B21) 2022; 9
Sung (B5) 2021; 713
Almendros (B89) 2016; 150
Lv (B102) 2023; 8
Wang (B105) 2022; 13
Huang (B48) 2019; 7
Marriott (B24) 2023; 1644
Cubillos-Zapata (B62) 2019; 53
Mackillop (B72) 1983; 70
Guo (B73) 2022; 87
Kang (B81) 2020; 10
Li (B98) 2021; 24
Romero-Garcia (B52) 2016; 7
Cui (B71) 2023; 122
Stern (B83) 2021; 11
Hao (B76) 2021; 22
Azarbarzin (B109) 2019; 40
Pan (B40) 2016; 201
Cabezas (B7) 2019; 972
Shin (B82) 2020; 12
Kendzerska (B28) 2021; 302
Yuan (B103) 2005; 280
Li (B104) 2022; 21
Gómez-Olivas (B107) 2023; 164
Xiong (B31) 2022; 12
Liu (B44) 2020; 70
Park (B33) 2023; 13
Chao (B97) 2020; 521
Zou (B60) 2016; 8
Liu (B87) 2021; 11
Dempsey (B12) 2010; 901
Wang (B100) 2021; 14
Riera-Domingo (B50) 2020; 100
Chang (B1) 2023; 137
Wang (B94) 2023; 18
Senaratna (B3) 2017; 34
Li (B37) 2022; 263
Cortese (B95) 2015; 6
Idris (B14) 2009; 118
Cubillos-Zapata (B84) 2020; 34
Desai (B46) 2023; 91
Cheong (B6) 2022; 193
Huang (B8) 2020; 167
Boussiotis (B59) 2016; 375
Campillo (B69) 2017; 7
Wu (B108) 2023; 41
Leiter (B11) 2023; 209
Zhang (B80) 2019; 21
Liu (B90) 2022; 26
Ngaha (B78) 2023; 15
Justeau (B23) 2020; 1586
Malhotra (B110) 2021; 44
Sivam (B112) 2022; 18
Almendros (B67) 2014; 189
Cubillos-Zapata (B63) 2017; 50
References_xml – volume: 302
  start-page: 295
  year: 2021
  ident: B28
  article-title: Obstructive sleep apnea and incident cancer: a large retrospective multicenter clinical cohort study
  publication-title: Cancer Epidemiol Biomarkers Prev
  doi: 10.1158/1055-9965.EPI-20-0975
  contributor:
    fullname: Kendzerska
– volume: 201
  year: 2016
  ident: B40
  article-title: Obstructive sleep apnoea and risks of all-cause mortality: preliminary evidence from prospective cohort studies
  publication-title: Sleep Breath
  doi: 10.1007/s11325-015-1295-7
  contributor:
    fullname: Pan
– volume: 70
  start-page: 9
  year: 1983
  ident: B72
  article-title: A stem cell model of human tumor growth: implications for tumor cell clonogenic assays
  publication-title: J Natl Cancer Inst
  doi: 10.1016/S0022-5347(17)51493-7
  contributor:
    fullname: Mackillop
– volume: 7
  year: 2017
  ident: B69
  article-title: Role of cyclooxygenase-2 on intermittent hypoxia-induced lung tumor Malignancy in a mouse model of sleep apnea
  publication-title: Sci Rep
  doi: 10.1038/srep44693
  contributor:
    fullname: Campillo
– volume: 118
  year: 2009
  ident: B14
  article-title: Obstructive sleep apnoea in patients with type 2 diabetes: aetiology and implications for clinical care
  publication-title: Diabetes Obes Metab
  doi: 10.1111/j.1463-1326.2009.01045.x
  contributor:
    fullname: Idris
– volume: 91
  year: 2023
  ident: B46
  article-title: Perioperative immune checkpoint inhibition in early-stage non-small cell lung cancer: a review
  publication-title: JAMA Oncol
  doi: 10.1001/jamaoncol.2022.5389
  contributor:
    fullname: Desai
– volume: 41
  year: 2023
  ident: B108
  article-title: Optimizing lung cancer screening with risk prediction: current challenges and the emerging role of biomarkers
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.23.01060
  contributor:
    fullname: Wu
– volume: 31
  start-page: 210256
  year: 2022
  ident: B2
  article-title: Bidirectional relationships of comorbidity with obstructive sleep apnoea
  publication-title: Eur Respir Rev
  doi: 10.1183/16000617.0256-2021
  contributor:
    fullname: Gleeson
– volume: 901
  start-page: 47
  year: 2010
  ident: B12
  article-title: Pathophysiology of sleep apnea
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00043.2008
  contributor:
    fullname: Dempsey
– volume: 150
  year: 2016
  ident: B89
  article-title: Tumor cell Malignant properties are enhanced by circulating exosomes in sleep apnea
  publication-title: Chest
  doi: 10.1016/j.chest.2016.08.1438
  contributor:
    fullname: Almendros
– volume: 21
  year: 2019
  ident: B80
  article-title: Anti-tumor effect of endostatin in a sleep-apnea mouse model with tumor
  publication-title: Clin Transl Oncol
  doi: 10.1007/s12094-018-1955-8
  contributor:
    fullname: Zhang
– volume: 34219
  year: 2000
  ident: B13
  article-title: Prospective study of the association between sleep-disordered breathing and hypertension
  publication-title: N Engl J Med
  doi: 10.1056/NEJM200005113421901
  contributor:
    fullname: Peppard
– volume: 7
  year: 2016
  ident: B61
  article-title: The PD1:PD-L1/2 Pathway from discovery to clinical implementation
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2016.00550
  contributor:
    fullname: Bardhan
– volume: 189
  start-page: 593
  year: 2014
  ident: B67
  article-title: Intermittent hypoxia-induced changes in tumor-associated macrophages and tumor Malignancy in a mouse model of sleep apnea
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201310-1830OC
  contributor:
    fullname: Almendros
– volume: 28
  year: 2023
  ident: B58
  article-title: Obstructive sleep apnea promotes the progression of lung cancer by modulating cancer cell invasion and cancer-associated fibroblast activation via TGFβ signaling
  publication-title: Redox Rep
  doi: 10.1080/13510002.2023.2279813
  contributor:
    fullname: Cui
– volume: 44
  year: 2021
  ident: B110
  article-title: Metrics of sleep apnea severity: beyond the apnea-hypopnea index
  publication-title: Sleep
  doi: 10.1093/sleep/zsab030
  contributor:
    fullname: Malhotra
– volume: 20
  year: 2023
  ident: B93
  article-title: Rare molecular subtypes of lung cancer
  publication-title: Nat Rev Clin Oncol
  doi: 10.1038/s41571-023-00733-6
  contributor:
    fullname: Harada
– volume: 122
  year: 2023
  ident: B71
  article-title: Intermittent hypoxia inhibits anti-tumor immune response via regulating PD-L1 expression in lung cancer cells and tumor-associated macrophages
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2023.110652
  contributor:
    fullname: Cui
– volume: 137
  year: 2023
  ident: B1
  article-title: International consensus statement on obstructive sleep apnea
  publication-title: Int Forum Allergy Rhinol
  doi: 10.1002/alr.23079
  contributor:
    fullname: Chang
– volume: 1644
  year: 2023
  ident: B24
  article-title: Does OSA increase risk for cancer?: a large historical sleep clinic cohort study
  publication-title: Chest
  doi: 10.1016/j.chest.2023.04.043
  contributor:
    fullname: Marriott
– volume: 73
  year: 2023
  ident: B91
  article-title: Clinical insights into small cell lung cancer: tumor heterogeneity, diagnosis, therapy, and future directions
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21785
  contributor:
    fullname: Megyesfalvi
– volume: 40
  start-page: 5
  year: 2018
  ident: B29
  article-title: [Report of cancer incidence and mortality in China, 2014]
  publication-title: Zhonghua Zhong Liu Za Zhi
  doi: 10.3760/cma.j.issn.0253-3766.2018.01.002
  contributor:
    fullname: Chen
– volume: 103
  start-page: 51
  year: 2023
  ident: B16
  article-title: Prevalence of sleep-related breathing disorders and associated risk factors among people with dementia: a meta-analysis
  publication-title: Sleep Med
  doi: 10.1016/j.sleep.2023.01.020
  contributor:
    fullname: Aini
– volume: 15
  year: 2023
  ident: B78
  article-title: Angiogenesis in lung cancer: understanding the roles of growth factors
  publication-title: Cancers (Basel)
  doi: 10.3390/cancers15184648
  contributor:
    fullname: Ngaha
– volume: 15
  year: 2020
  ident: B86
  article-title: Exosome: a review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications
  publication-title: Int J Nanomedicine
  doi: 10.2147/IJN.S264498
  contributor:
    fullname: Zhang
– volume: 19
  start-page: 495
  year: 2019
  ident: B92
  article-title: Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy
  publication-title: Nat Rev Cancer
  doi: 10.1038/s41568-019-0179-8
  contributor:
    fullname: Skoulidis
– volume: 15
  year: 2019
  ident: B111
  article-title: The odds ratio product (an objective sleep depth measure): normal values, repeatability, and change with CPAP in patients with OSA
  publication-title: J Clin Sleep Med
  doi: 10.5664/jcsm.7812
  contributor:
    fullname: Penner
– volume: 12
  year: 2022
  ident: B31
  article-title: The incidence of cancer is increased in hospitalized adult patients with obstructive sleep apnea in China: a retrospective cohort study
  publication-title: Front Oncol
  doi: 10.3389/fonc.2022.856121
  contributor:
    fullname: Xiong
– volume: 18
  year: 2022
  ident: B112
  article-title: Cardiopulmonary coupling and serum cardiac biomarkers in obesity hypoventilation syndrome and obstructive sleep apnea with morbid obesity
  publication-title: J Clin Sleep Med
  doi: 10.5664/jcsm.9804
  contributor:
    fullname: Sivam
– volume: 18
  start-page: 31
  year: 2023
  ident: B94
  article-title: SCLC: epidemiology, risk factors, genetic susceptibility, molecular pathology, screening, and early detection
  publication-title: J Thorac Oncol
  doi: 10.1016/j.jtho.2022.10.002
  contributor:
    fullname: Wang
– volume: 713
  year: 2021
  ident: B5
  article-title: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21660
  contributor:
    fullname: Sung
– volume: 34
  start-page: 70
  year: 2017
  ident: B3
  article-title: Prevalence of obstructive sleep apnea in the general population: a systematic review
  publication-title: Sleep Med Rev
  doi: 10.1016/j.smrv.2016.07.002
  contributor:
    fullname: Senaratna
– volume: 398
  year: 2016
  ident: B25
  article-title: Sleep apnea and cancer: analysis of a nationwide population sample
  publication-title: Sleep
  doi: 10.5665/sleep.6004
  contributor:
    fullname: Gozal
– volume: 37
  start-page: 45
  year: 2018
  ident: B39
  article-title: Phenotypic approaches to obstructive sleep apnoea - new pathways for targeted therapy
  publication-title: Sleep Med Rev
  doi: 10.1016/j.smrv.2016.12.003
  contributor:
    fullname: Eckert
– volume: 443
  year: 2021
  ident: B27
  article-title: Associations of self-reported obstructive sleep apnea with total and site-specific cancer risk in older women: a prospective study
  publication-title: Sleep
  doi: 10.1093/sleep/zsaa198
  contributor:
    fullname: Huang
– volume: 142
  year: 2019
  ident: B47
  article-title: Effect of cyclical intermittent hypoxia on Ad5CMVCre induced solitary lung cancer progression and spontaneous metastases in the KrasG12D+; p53fl/fl; myristolated p110fl/fl ROSA-gfp mouse
  publication-title: PloS One
  doi: 10.1371/journal.pone.0212930
  contributor:
    fullname: Guo
– volume: 276
  year: 2019
  ident: B51
  article-title: Differential expression of immune markers in the patients with obstructive sleep apnea/hypopnea syndrome
  publication-title: Eur Arch Otorhinolaryngol
  doi: 10.1007/s00405-018-5219-6
  contributor:
    fullname: Xie
– volume: 1586
  year: 2020
  ident: B23
  article-title: Association between nocturnal hypoxemia and cancer incidence in patients investigated for OSA: data from a large multicenter French cohort
  publication-title: Chest
  doi: 10.1016/j.chest.2020.06.055
  contributor:
    fullname: Justeau
– volume: 10
  year: 2024
  ident: B85
  article-title: Sleep apnoea increases biomarkers of immune evasion, lymphangiogenesis and tumour cell aggressiveness in high-risk patients and those with established lung cancer
  publication-title: ERJ Open Res
  doi: 10.1183/23120541.00777-2023
  contributor:
    fullname: Cubillos-Zapata
– volume: 70
  start-page: 88
  year: 2020
  ident: B44
  article-title: Short-term prognostic effects of circulating regulatory T-Cell suppressive function and vascular endothelial growth factor level in patients with non-small cell lung cancer and obstructive sleep apnea
  publication-title: Sleep Med
  doi: 10.1016/j.sleep.2020.02.009
  contributor:
    fullname: Liu
– volume: 18
  year: 2022
  ident: B79
  article-title: VEGF/VEGFR-targeted therapy and immunotherapy in non-small cell lung cancer: targeting the tumor microenvironment
  publication-title: Int J Biol Sci
  doi: 10.7150/ijbs.70958
  contributor:
    fullname: Zhao
– volume: 100
  start-page: 1
  year: 2020
  ident: B50
  article-title: Immunity, hypoxia, and metabolism-the menage a trois of cancer: implications for immunotherapy
  publication-title: Physiol Rev
  doi: 10.1016/j.cub.2020.06.081
  contributor:
    fullname: Riera-Domingo
– volume: 52
  year: 2002
  ident: B43
  article-title: Pathological significance of vascular endothelial growth factor A isoform expression in human cancer
  publication-title: Pathol Int
  doi: 10.1046/j.1440-1827.2002.01367.x
  contributor:
    fullname: Nakamura
– volume: 107
  year: 2023
  ident: B101
  article-title: Implications of obstructive sleep apnea in lung adenocarcinoma: a valuable omission in cancer prognosis and immunotherapy
  publication-title: Sleep Med
  doi: 10.1016/j.sleep.2023.05.013
  contributor:
    fullname: Qi
– volume: 167
  year: 2020
  ident: B8
  article-title: Severe OSA associated with higher risk of mortality in stage III and IV lung cancer
  publication-title: J Clin Sleep Med
  doi: 10.5664/jcsm.8432
  contributor:
    fullname: Huang
– volume: 190
  start-page: 53
  year: 2011
  ident: B17
  article-title: Cognition and daytime functioning in sleep-related breathing disorders
  publication-title: Prog Brain Res
  doi: 10.1016/B978-0-444-53817-8.00003-7
  contributor:
    fullname: Jackson
– volume: 42
  start-page: 221
  year: 2023
  ident: B88
  article-title: Exosome nanovesicles as potential biomarkers and immune checkpoint signaling modulators in lung cancer microenvironment: recent advances and emerging concepts
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/s13046-023-02753-7
  contributor:
    fullname: Khan
– volume: 8
  year: 2017
  ident: B99
  article-title: Target of obstructive sleep apnea syndrome merge lung cancer: based on big data platform
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.15372
  contributor:
    fullname: Li
– volume: 13
  year: 2023
  ident: B33
  article-title: Incidence disparities of obstructive sleep apnea-associated lung cancer by gender; Korean National Health Insurance data analysis
  publication-title: Front Oncol
  doi: 10.3389/fonc.2023.1214279
  contributor:
    fullname: Park
– volume: 971
  start-page: 15
  year: 2019
  ident: B32
  article-title: Increased risk for cancer in young patients with severe obstructive sleep apnea
  publication-title: Respiration
  doi: 10.1159/000486577
  contributor:
    fullname: Brenner
– volume: 40
  year: 2017
  ident: B55
  article-title: Altered CD8+ T-cell lymphocyte function and TC1 cell stemness contribute to enhanced Malignant tumor properties in murine models of sleep apnea
  publication-title: Sleep
  doi: 10.1093/sleep/zsw040
  contributor:
    fullname: Akbarpour
– volume: 209
  year: 2023
  ident: B11
  article-title: The global burden of lung cancer: current status and future trends
  publication-title: Nat Rev Clin Oncol
  doi: 10.1038/s41571-023-00798-3
  contributor:
    fullname: Leiter
– volume: 12
  year: 2020
  ident: B82
  article-title: Midkine is a potential therapeutic target of tumorigenesis, angiogenesis, and metastasis in non-small cell lung cancer
  publication-title: Cancers (Basel)
  doi: 10.3390/cancers12092402
  contributor:
    fullname: Shin
– volume: 11
  start-page: 14616
  year: 2021
  ident: B83
  article-title: Serum midkine as non-invasive biomarker for detection and prognosis of non-small cell lung cancer
  publication-title: Sci Rep
  doi: 10.1038/s41598-021-94272-8
  contributor:
    fullname: Stern
– volume: 89
  year: 2023
  ident: B41
  article-title: Artificial intelligence in lung cancer diagnosis and prognosis: current application and future perspective
  publication-title: Semin Cancer Biol
  doi: 10.1016/j.semcancer.2023.01.006
  contributor:
    fullname: Huang
– volume: 1624
  year: 2020
  ident: B26
  article-title: The association of sleep apnea and cancer in veterans
  publication-title: Otolaryngol Head Neck Surg
  doi: 10.1177/0194599819900487
  contributor:
    fullname: Jara
– volume: 37
  start-page: 709
  year: 2014
  ident: B106
  article-title: Treatment of obstructive sleep apnea alters cancer-associated transcriptional signatures in circulating leukocytes
  publication-title: Sleep
  doi: 10.5665/sleep.3574
  contributor:
    fullname: Gharib
– volume: 972
  year: 2019
  ident: B7
  article-title: Sleep disordered breathing is highly prevalent in patients with lung cancer: results of the sleep apnea in lung cancer study
  publication-title: Respiration
  doi: 10.1159/000492273
  contributor:
    fullname: Cabezas
– volume: 13
  year: 2022
  ident: B105
  article-title: Effects of chronic intermittent hypoxia and chronic sleep fragmentation on gut microbiome, serum metabolome, liver and adipose tissue morphology
  publication-title: Front Endocrinol (Lausanne)
  doi: 10.3389/fendo.2022.820939
  contributor:
    fullname: Wang
– volume: 22
  start-page: 25
  year: 2022
  ident: B56
  article-title: Overcoming TGFbeta-mediated immune evasion in cancer
  publication-title: Nat Rev Cancer
  doi: 10.1038/s41568-021-00413-6
  contributor:
    fullname: Tauriello
– volume: 45
  year: 2021
  ident: B75
  article-title: ESM1/HIF−1α pathway modulates chronic intermittent hypoxia−induced non−small−cell lung cancer proliferation, stemness and epithelial−mesenchymal transition
  publication-title: Oncol Rep
  doi: 10.3892/or.2020.7913
  contributor:
    fullname: Gu
– volume: 84
  start-page: 195
  year: 2021
  ident: B22
  article-title: Obstructive sleep apnea and incidence of Malignant tumors: a meta-analysis
  publication-title: Sleep Med
  doi: 10.1016/j.sleep.2021.05.029
  contributor:
    fullname: Cheng
– volume: 173
  start-page: 94
  year: 2017
  ident: B38
  article-title: Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: health impacts and mechanisms of circadian disruption
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2017.02.008
  contributor:
    fullname: Touitou
– volume: 301
  start-page: 36
  year: 2019
  ident: B53
  article-title: Macrophages and metabolism in the tumor microenvironment
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2019.06.001
  contributor:
    fullname: Vitale
– volume: 361
  year: 2015
  ident: B70
  article-title: Adipose tissue macrophage polarization by intermittent hypoxia in a mouse model of OSA: effect of tumor microenvironment
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2015.03.010
  contributor:
    fullname: Almendros
– volume: 14
  year: 2023
  ident: B96
  article-title: Promising immunotherapeutic targets in lung cancer based on single-cell RNA sequencing
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2023.1148061
  contributor:
    fullname: Xue
– volume: 30
  year: 2020
  ident: B49
  article-title: The tumor microenvironment
  publication-title: Curr Biol
  doi: 10.21037/atm.2019.01.44
  contributor:
    fullname: Anderson
– volume: 33
  year: 2012
  ident: B65
  article-title: Differential macrophage programming in the tumor microenvironment
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2011.12.001
  contributor:
    fullname: Ruffell
– volume: 27
  year: 2020
  ident: B68
  article-title: Lung cancer aggressiveness in an intermittent hypoxia murine model of postmenopausal sleep apnea
  publication-title: Menopause
  doi: 10.1097/GME.0000000000001526
  contributor:
    fullname: Torres
– volume: 6
  year: 2015
  ident: B95
  article-title: Tumor circulating DNA profiling in xenografted mice exposed to intermittent hypoxia
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.2785
  contributor:
    fullname: Cortese
– volume: 731
  start-page: 17
  year: 2023
  ident: B4
  article-title: Cancer statistics, 2023
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21763
  contributor:
    fullname: Siegel
– volume: 63
  year: 2019
  ident: B30
  article-title: Obstructive sleep apnea and nocturnal hypoxemia are associated with an increased risk of lung cancer
  publication-title: Sleep Med
  doi: 10.1016/j.sleep.2019.05.011
  contributor:
    fullname: Seijo
– volume: 53
  start-page: 1801298
  year: 2019
  ident: B62
  article-title: Soluble PD-L1 is a potential biomarker of cutaneous melanoma aggressiveness and metastasis in obstructive sleep apnoea patients
  publication-title: Eur Respir J
  doi: 10.1183/13993003.01298-2018
  contributor:
    fullname: Cubillos-Zapata
– volume: 362
  year: 2013
  ident: B18
  article-title: Memory and obstructive sleep apnea: a meta-analysis
  publication-title: Sleep
  doi: 10.5665/sleep.2374
  contributor:
    fullname: Wallace
– volume: 145
  year: 2022
  ident: B19
  article-title: Sleep-disordered breathing in newly diagnosed patients of lung cancer
  publication-title: Cureus
  doi: 10.7759/cureus.25230
  contributor:
    fullname: Bhaisare
– volume: 24
  year: 2021
  ident: B98
  article-title: Intermittent hypoxia-induced downregulation of microRNA-320b promotes lung cancer tumorigenesis by increasing CDT1 via USP37
  publication-title: Mol Ther Nucleic Acids
  doi: 10.1016/j.omtn.2020.12.023
  contributor:
    fullname: Li
– volume: 263
  year: 2022
  ident: B37
  article-title: Sleep duration and health outcomes: an umbrella review
  publication-title: Sleep Breath
  doi: 10.1007/s11325-021-02458-1
  contributor:
    fullname: Li
– volume: 280
  year: 2005
  ident: B103
  article-title: Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M407706200
  contributor:
    fullname: Yuan
– volume: 14
  year: 2021
  ident: B100
  article-title: Key Common genes in obstructive sleep apnea and lung cancer are associated with prognosis of lung cancer patients
  publication-title: Int J Gen Med
  doi: 10.2147/IJGM.S330681
  contributor:
    fullname: Wang
– volume: 26
  start-page: 893
  year: 2022
  ident: B90
  article-title: Extracellular vesicles derived from lung cancer cells exposed to intermittent hypoxia upregulate programmed death ligand 1 expression in macrophages
  publication-title: Sleep Breath
  doi: 10.1007/s11325-021-02369-1
  contributor:
    fullname: Liu
– volume: 1582
  year: 2020
  ident: B9
  article-title: Update on persistent excessive daytime sleepiness in OSA
  publication-title: Chest
  doi: 10.1016/j.chest.2020.02.036
  contributor:
    fullname: Javaheri
– volume: 10
  start-page: 1854
  year: 2020
  ident: B81
  article-title: Intermittent hypoxia exacerbates tumor progression in a mouse model of lung cancer
  publication-title: Sci Rep
  doi: 10.1038/s41598-020-58906-7
  contributor:
    fullname: Kang
– volume: 164
  year: 2023
  ident: B107
  article-title: Role of sleep apnea and long-term CPAP treatment in the prognosis of patients with melanoma: a prospective multicenter study of 443 patients
  publication-title: Chest
  doi: 10.1016/j.chest.2023.06.012
  contributor:
    fullname: Gómez-Olivas
– volume: 2910
  year: 2018
  ident: B34
  article-title: Sleep apnea and subsequent cancer incidence
  publication-title: Cancer Causes Control
  doi: 10.1007/s10552-018-1073-5
  contributor:
    fullname: Sillah
– volume: 257
  start-page: 690
  year: 2020
  ident: B36
  article-title: Global burden of sleep-disordered breathing and its implications
  publication-title: Respirology
  doi: 10.1111/resp.13838
  contributor:
    fullname: Lyons
– volume: 7
  year: 2016
  ident: B52
  article-title: Lactate Contribution to the tumor microenvironment: mechanisms, effects on immune cells and therapeutic relevance
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2016.00052
  contributor:
    fullname: Romero-Garcia
– volume: 394
  year: 2019
  ident: B42
  article-title: Relationship between occurrence and progression of lung cancer and nocturnal intermittent hypoxia, apnea and daytime sleepiness
  publication-title: Curr Med Sci
  doi: 10.1007/s11596-019-2075-6
  contributor:
    fullname: Liu
– volume: 160
  year: 2019
  ident: B74
  article-title: Lung cancer stem cells: origin, features, maintenance mechanisms and therapeutic targeting
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2018.12.010
  contributor:
    fullname: Heng
– volume: 21
  start-page: 25
  year: 2022
  ident: B104
  article-title: Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring
  publication-title: Mol Cancer
  doi: 10.1186/s12943-022-01505-z
  contributor:
    fullname: Li
– volume: 50
  start-page: 1700833
  year: 2017
  ident: B63
  article-title: Hypoxia-induced PD-L1/PD-1 crosstalk impairs T-cell function in sleep apnoea
  publication-title: Eur Respir J
  doi: 10.1183/13993003.00833-2017
  contributor:
    fullname: Cubillos-Zapata
– volume: 17
  start-page: 89
  year: 2022
  ident: B64
  article-title: Tumor and tumor-associated acrophage programmed death-ligand 1 expression is associated with adjuvant chemotherapy benefit in lung adenocarcinoma
  publication-title: J Thorac Oncol
  doi: 10.1016/j.jtho.2021.09.009
  contributor:
    fullname: Gross
– volume: 8
  start-page: 218
  year: 2023
  ident: B102
  article-title: Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
  publication-title: Signal Transduct Target Ther
  doi: 10.1038/s41392-023-01496-3
  contributor:
    fullname: Lv
– volume: 274
  year: 2023
  ident: B20
  article-title: Associations among sleep-disordered breathing, sleep quality, and lung cancer in Korean patients
  publication-title: Sleep Breath
  doi: 10.1007/s11325-022-02750-8
  contributor:
    fullname: Lee
– volume: 8
  year: 2016
  ident: B60
  article-title: PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: mechanisms, response biomarkers, and combinations
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.aad7118
  contributor:
    fullname: Zou
– volume: 40
  year: 2019
  ident: B109
  article-title: The hypoxic burden of sleep apnoea predicts cardiovascular disease-related mortality: the Osteoporotic Fractures in Men Study and the Sleep Heart Health Study
  publication-title: Eur Heart J
  doi: 10.1093/eurheartj/ehy624
  contributor:
    fullname: Azarbarzin
– volume: 22
  start-page: 58
  year: 2021
  ident: B76
  article-title: Chronic intermittent hypoxia promoted lung cancer stem cell-like properties via enhancing Bach1 expression
  publication-title: Respir Res
  doi: 10.1186/s12931-021-01655-6
  contributor:
    fullname: Hao
– volume: 11
  year: 2021
  ident: B87
  article-title: The biology, function, and applications of exosomes in cancer
  publication-title: Acta Pharm Sin B
  doi: 10.1016/j.apsb.2021.01.001
  contributor:
    fullname: Liu
– volume: 9
  year: 2022
  ident: B21
  article-title: Development and validation of a prognostic nomogram in lung cancer with obstructive sleep apnea syndrome
  publication-title: Front Med (Lausanne)
  doi: 10.3389/fmed.2022.810907
  contributor:
    fullname: Liu
– volume: 7
  start-page: 97
  year: 2019
  ident: B48
  article-title: Intermittent hypoxia enhances the tumor programmed death ligand 1 expression in a mouse model of sleep apnea
  publication-title: Ann Transl Med
  doi: 10.21037/atm.2019.01.44
  contributor:
    fullname: Huang
– volume: 49
  start-page: 1602456
  year: 2017
  ident: B57
  article-title: Monocytes inhibit NK activity via TGF-β in patients with obstructive sleep apnoea
  publication-title: Eur Respir J
  doi: 10.1183/13993003.02456-2016
  contributor:
    fullname: Hernández-Jiménez
– volume: 193
  year: 2022
  ident: B6
  article-title: Obstructive sleep apnea and lung cancer: a systematic review and meta-analysis
  publication-title: Ann Am Thorac Soc
  doi: 10.1513/AnnalsATS.202108-960OC
  contributor:
    fullname: Cheong
– volume: 27
  start-page: 44
  year: 2022
  ident: B77
  article-title: Effect of chronic intermittent hypoxia-induced HIF-1α/ATAD2 expression on lung cancer stemness
  publication-title: Cell Mol Biol Lett
  doi: 10.1186/s11658-022-00345-5
  contributor:
    fullname: Hao
– volume: 87
  year: 2022
  ident: B73
  article-title: The role of stem cells in small-cell lung cancer: evidence from chemoresistance to immunotherapy
  publication-title: Semin Cancer Biol
  doi: 10.1016/j.semcancer.2022.11.006
  contributor:
    fullname: Guo
– volume: 521
  start-page: 499
  year: 2020
  ident: B97
  article-title: ALKBH5-m(6)A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2019.10.145
  contributor:
    fullname: Chao
– volume: 74
  year: 2014
  ident: B54
  article-title: Fragmented sleep accelerates tumor growth and progression through recruitment of tumor-associated macrophages and TLR4 signaling
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-13-3014
  contributor:
    fullname: Hakim
– volume: 138
  year: 2021
  ident: B10
  article-title: The metastasizing mechanisms of lung cancer: recent advances and therapeutic challenges
  publication-title: BioMed Pharmacother
  doi: 10.1016/j.biopha.2021.111450
  contributor:
    fullname: Xie
– volume: 208
  year: 2023
  ident: B35
  article-title: Obstructive sleep apnoea heterogeneity and cardiovascular disease
  publication-title: Nat Rev Cardiol
  doi: 10.1038/s41569-023-00846-6
  contributor:
    fullname: Redline
– volume: 34
  year: 2020
  ident: B84
  article-title: Proangiogenic factor midkine is increased in melanoma patients with sleep apnea and induces tumor cell proliferation
  publication-title: FASEB J
  doi: 10.1096/fj.202001247RR
  contributor:
    fullname: Cubillos-Zapata
– volume: 375
  year: 2016
  ident: B59
  article-title: Molecular and biochemical aspects of the PD-1 checkpoint pathway
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra1514296
  contributor:
    fullname: Boussiotis
– volume: 112
  year: 2023
  ident: B15
  article-title: Prevalence and clinical characteristics of sleep disorders in chronic obstructive pulmonary disease: a systematic review and meta-analysis
  publication-title: Sleep Med
  doi: 10.1016/j.sleep.2023.10.034
  contributor:
    fullname: Du
– volume: 401
  start-page: 390
  year: 2023
  ident: B45
  article-title: Lung cancer screening
  publication-title: Lancet
  doi: 10.1016/S0140-6736(22)01694-4
  contributor:
    fullname: Adams
– volume: 11
  year: 2021
  ident: B66
  article-title: Research trends in pharmacological modulation of tumor-associated macrophages
  publication-title: Clin Transl Med
  doi: 10.1002/ctm2.288
  contributor:
    fullname: Wang
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Snippet Despite undeniable advances in modern medicine, lung cancer still has high morbidity and mortality rates. Lung cancer is preventable and treatable, and it is...
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SubjectTerms epidemiology
Immunology
intermittent hypoxia
lung cancer
obstructive sleep apnea
tumor associated macrophages
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Title A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic options
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