CD8+ T cell-mediated suppression of HIV long terminal repeat-driven gene expression is not associated with improved clinical status

• Published in: AIDS (London) Vol. 11; no. 5; pp. 581 - 586
• Main Authors: COPELAND, K. F. T, LEITH, J. G, MCKAY, P. J, KELLEHER, L, SMAILL, F. M, ROSENTHAL, K. L
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.04.1997
• Subjects: AIDS/HIV; Biological and medical sciences; CD4-CD8 Ratio; CD8-Positive T-Lymphocytes - immunology; Cells, Cultured; Cytotoxicity, Immunologic; Gene Expression Regulation, Viral; HIV Infections - immunology; HIV Infections - physiopathology; HIV Long Terminal Repeat - genetics; HIV-1 - genetics; human immunodeficiency virus; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Medical sciences; Prognosis; Human; Immunopathology; Cell culture; Pathogenesis; AIDS; Cellular immunity; Gene expression; Immune deficiency; In vitro; Infection; Numeration; Clinical stage; Viral disease; T-Lymphocyte; Inhibition; LTR sequence

To determine the associations between the suppression of HIV-1 long terminal repeat (LTR)-mediated gene expression by CD8+ T-cell supernatants and clinical correlates of well-being, including CD4+ and CD8+ T-cell counts, beta-chemokine production and clinical stage of disease. Culture supernatants o...