Dysregulated cytokine and oxidative response in hyper-glycolytic monocytes in obesity

• Published in: Frontiers in immunology Vol. 15; p. 1416543
• Main Authors: Radushev, Veselina, Karkossa, Isabel, Berg, Janina, von Bergen, Martin, Engelmann, Beatrice, Rolle-Kampczyk, Ulrike, Blüher, Matthias, Wagner, Ulf, Schubert, Kristin, Rossol, Manuela
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 10.07.2024
• Subjects: Adult; Cytokines - metabolism; Diabetes Mellitus, Type 2 - immunology; Diabetes Mellitus, Type 2 - metabolism; Female; Glucose Intolerance - immunology; Glucose Intolerance - metabolism; Glycolysis; Humans; IL-8; Immunology; immunometabolism; Male; Middle Aged; monocytes; Monocytes - immunology; Monocytes - metabolism; obesity; Obesity - immunology; Obesity - metabolism; Oxidative Stress; Proteomics - methods; respiratory burst; monocytes; IL-8; immunometabolism; obesity; respiratory burst

Obesity is associated with a plethora of health complications, including increased susceptibility to infections or decreased vaccine efficacy, partly due to dysregulated immune responses. Monocytes play a crucial role in innate immunity, yet their functional alterations in obesity remain poorly unde...