Convalescent human IgG, but not IgM, from COVID-19 survivors confers dose-dependent protection against SARS-CoV-2 replication and disease in hamsters

• Published in: Frontiers in immunology Vol. 14; p. 1138629
• Main Authors: King, Hannah A. D., Dussupt, Vincent, Mendez-Rivera, Letzibeth, Slike, Bonnie M., Tran, Ursula, Jackson, Nathan D., Barkei, Erica, Zemil, Michelle, Tourtellott-Fogt, Emily, Kuklis, Caitlin H., Soman, Sandrine, Ahmed, Aslaa, Porto, Maciel, Kitajewski, Christopher, Spence, Brittany, Benetiene, Dalia, Wieczorek, Lindsay, Kar, Swagata, Gromowski, Gregory, Polonis, Victoria R., Krebs, Shelly J., Modjarrad, Kayvon, Bolton, Diane L.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 21.03.2023
• Subjects: Animals; Antibodies, Neutralizing; antibody; COVID-19; Cricetinae; hamster; Humans; IgG; IgM; Immunoglobulin G; Immunology; Mesocricetus; Pandemics; passive transfer; SARS-CoV-2; Survivors; IgG; SARS-CoV-2; antibody; passive transfer; hamster; IgM

Antibody therapeutic strategies have served an important role during the COVID-19 pandemic, even as their effectiveness has waned with the emergence of escape variants. Here we sought to determine the concentration of convalescent immunoglobulin required to protect against disease from SARS-CoV-2 in...