Organ-based characterization of B cells in patients with systemic lupus erythematosus

• Published in: Frontiers in immunology Vol. 16; p. 1509033
• Main Authors: Wang, Yunan, Zhao, Rui, Liang, Qian, Ni, Shiwen, Yang, Mei, Qiu, Liwei, Ji, Juan, Gu, Zhifeng, Dong, Chen
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2025
• Subjects: Animals; Autoantibodies - immunology; B cell; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Humans; Immunology; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - pathology; organ damage; organ specific features; Organ Specificity - immunology; systemic lupus erythematosus; therapy strategies; B cell; systemic lupus erythematosus; organ specific features; therapy strategies; organ damage

Systemic lupus erythematosus (SLE) is a chronic, inflammatory, and progressive autoimmune disease. The unclear pathogenesis, high heterogeneity, and prolonged course of the disease present significant challenges for effective clinical management of lupus patients. Dysregulation of the immune system...