Organ-based characterization of B cells in patients with systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a chronic, inflammatory, and progressive autoimmune disease. The unclear pathogenesis, high heterogeneity, and prolonged course of the disease present significant challenges for effective clinical management of lupus patients. Dysregulation of the immune system...

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Published inFrontiers in immunology Vol. 16; p. 1509033
Main Authors Wang, Yunan, Zhao, Rui, Liang, Qian, Ni, Shiwen, Yang, Mei, Qiu, Liwei, Ji, Juan, Gu, Zhifeng, Dong, Chen
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 2025
Subjects
Animals
Autoantibodies - immunology
B cell
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
Humans
Immunology
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - pathology
organ damage
organ specific features
Organ Specificity - immunology
systemic lupus erythematosus
therapy strategies
B cell
systemic lupus erythematosus
organ specific features
therapy strategies
organ damage
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Abstract Systemic lupus erythematosus (SLE) is a chronic, inflammatory, and progressive autoimmune disease. The unclear pathogenesis, high heterogeneity, and prolonged course of the disease present significant challenges for effective clinical management of lupus patients. Dysregulation of the immune system and disruption of immune tolerance, particularly through the abnormal activation of B lymphocytes and the production of excessive autoantibodies, lead to widespread inflammation and tissue damage, resulting in multi-organ impairment. Currently, there is no systematic review that examines the specificity of B cell characteristics and pathogenic mechanisms across various organs. This paper reviews current research on B cells in lupus patients and summarizes the distinct characteristics of B cells in different organs. By integrating clinical manifestations of organ damage in patients with a focus on the organ-specific features of B cells, we provide a new perspective on enhancing the efficacy of lupus-targeted B cell therapy strategies.
AbstractList Systemic lupus erythematosus (SLE) is a chronic, inflammatory, and progressive autoimmune disease. The unclear pathogenesis, high heterogeneity, and prolonged course of the disease present significant challenges for effective clinical management of lupus patients. Dysregulation of the immune system and disruption of immune tolerance, particularly through the abnormal activation of B lymphocytes and the production of excessive autoantibodies, lead to widespread inflammation and tissue damage, resulting in multi-organ impairment. Currently, there is no systematic review that examines the specificity of B cell characteristics and pathogenic mechanisms across various organs. This paper reviews current research on B cells in lupus patients and summarizes the distinct characteristics of B cells in different organs. By integrating clinical manifestations of organ damage in patients with a focus on the organ-specific features of B cells, we provide a new perspective on enhancing the efficacy of lupus-targeted B cell therapy strategies.
Systemic lupus erythematosus (SLE) is a chronic, inflammatory, and progressive autoimmune disease. The unclear pathogenesis, high heterogeneity, and prolonged course of the disease present significant challenges for effective clinical management of lupus patients. Dysregulation of the immune system and disruption of immune tolerance, particularly through the abnormal activation of B lymphocytes and the production of excessive autoantibodies, lead to widespread inflammation and tissue damage, resulting in multi-organ impairment. Currently, there is no systematic review that examines the specificity of B cell characteristics and pathogenic mechanisms across various organs. This paper reviews current research on B cells in lupus patients and summarizes the distinct characteristics of B cells in different organs. By integrating clinical manifestations of organ damage in patients with a focus on the organ-specific features of B cells, we provide a new perspective on enhancing the efficacy of lupus-targeted B cell therapy strategies.Systemic lupus erythematosus (SLE) is a chronic, inflammatory, and progressive autoimmune disease. The unclear pathogenesis, high heterogeneity, and prolonged course of the disease present significant challenges for effective clinical management of lupus patients. Dysregulation of the immune system and disruption of immune tolerance, particularly through the abnormal activation of B lymphocytes and the production of excessive autoantibodies, lead to widespread inflammation and tissue damage, resulting in multi-organ impairment. Currently, there is no systematic review that examines the specificity of B cell characteristics and pathogenic mechanisms across various organs. This paper reviews current research on B cells in lupus patients and summarizes the distinct characteristics of B cells in different organs. By integrating clinical manifestations of organ damage in patients with a focus on the organ-specific features of B cells, we provide a new perspective on enhancing the efficacy of lupus-targeted B cell therapy strategies.
Author Ni, Shiwen
Liang, Qian
Yang, Mei
Gu, Zhifeng
Qiu, Liwei
Ji, Juan
Zhao, Rui
Wang, Yunan
Dong, Chen
AuthorAffiliation Department of Rheumatology, Research Center of Clinical Medicine, Research Center of Clinical Immunology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong University , Nantong , China
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Keywords B cell
systemic lupus erythematosus
organ specific features
therapy strategies
organ damage
Language English
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Erin Taylor, University of Mississippi Medical Center, United States
Shigeru Iwata, Wakayama Medical University, Japan
These authors have contributed equally to this work
Edited by: Joerg Wenzel, University Hospital Bonn, Germany
Reviewed by: Saeed Mohammadi, Golestan University of Medical Sciences, Iran
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Snippet Systemic lupus erythematosus (SLE) is a chronic, inflammatory, and progressive autoimmune disease. The unclear pathogenesis, high heterogeneity, and prolonged...
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SubjectTerms Animals
Autoantibodies - immunology
B cell
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
Humans
Immunology
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - pathology
organ damage
organ specific features
Organ Specificity - immunology
systemic lupus erythematosus
therapy strategies
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Title Organ-based characterization of B cells in patients with systemic lupus erythematosus
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