Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model

• Published in: Frontiers in immunology Vol. 15; p. 1360412
• Main Authors: Ahmed, Mohamed, Tezera, Liku B., Herbert, Nicholas, Chambers, Mark, Reichmann, Michaela T., Nargan, Kievershen, Kloverpris, Henrik, Karim, Farina, Hlatshwayo, Mbali, Madensein, Rajhmun, Habesh, Munir, Hoque, Monjural, Steyn, Adrie J.C., Elkington, Paul T., Leslie, Alasdair J.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 30.04.2024
• Subjects: Adult; Antigens, CD - genetics; Antigens, CD - metabolism; Biomimetics; CD200 receptor; Female; Humans; immune checkpoint; Immunology; innate immunity; Lung - immunology; Lung - metabolism; Lung - microbiology; Lung - pathology; Macrophages - immunology; Macrophages - metabolism; Male; Middle Aged; Monocytes - immunology; Monocytes - metabolism; Mycobacterium tuberculosis - immunology; Myeloid Cells - immunology; Myeloid Cells - metabolism; Orexin Receptors - metabolism; pulmonary infection; tuberculosis; Tuberculosis, Pulmonary - immunology; Tuberculosis, Pulmonary - microbiology; pulmonary infection; CD200 receptor; innate immunity; immune checkpoint; tuberculosis

A robust immune response is required for resistance to pulmonary tuberculosis (TB), the primary disease caused by Mycobacterium tuberculosis ( Mtb ). However, pharmaceutical inhibition of T cell immune checkpoint molecules can result in the rapid development of active disease in latently infected in...