Ring-closing metathesis approach to a 16-membered macrocycle of kendomycin

• Published in: Chemistry letters Vol. 36; no. 6; pp. 726 - 727
• Main Authors: Sengoku, Tetsuya, Uemura, Daisuke, Arimoto, Hirokazu
• Format: Journal Article
• Language: English
• Published: TOKYO Chemical Soc Japan 05.06.2007
• Subjects: Chemistry; Chemistry, Multidisciplinary; Physical Sciences; Science & Technology; FRAGMENT; (-)-KENDOMYCIN; BIOSYNTHESIS; STRATEGY

An approach to the macrocyclic core of kendomycin is described in which the Nozaki-Hiyama-Kishi coupling and a ring-closing olefin metathesis are the key reactions.