Involvement of Onuf's nucleus in amyotrophic lateral sclerosis
The Onufrowicz (Onuf's) nuclei from eight amyotrophic lateral sclerosis (ALS) cases and nine neurological control cases were studied histologically and morphometrically. To clarify the factors relating to the involvement of the Onuf's nucleus in ALS, we correlated the relationships among t...
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Published in | Journal of the neurological sciences Vol. 147; no. 1; pp. 81 - 88 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
20.03.1997
Elsevier Science |
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Abstract | The Onufrowicz (Onuf's) nuclei from eight amyotrophic lateral sclerosis (ALS) cases and nine neurological control cases were studied histologically and morphometrically. To clarify the factors relating to the involvement of the Onuf's nucleus in ALS, we correlated the relationships among the age at death, clinical duration, morphometric findings for Onuf's neurons, and neuronal numbers in the posteroposterolateral (PPL) nuclei in the ALS cases with those in neurological controls. Intracytoplasmic inclusions such as Bunina bodies, ubiquitin-reactive inclusions, and conglomerate inclusion were found in the Onuf's neurons in ALS, but not in the controls. The total number of Onuf's neurons in the ALS cases was not decreased, but that of normal-appearing neurons was decreased while that of atrophic neurons was increased. Significantly decreased perikaryal, nuclear and nucleolar areas and decreased perikaryal (P)/nuclear and P/nucleolar area ratios of Onuf's neurons were found in ALS, not only in the atrophic neurons but also in the normal-appearing neurons, compared with the controls. The shrinkage in Onuf's neurons of ALS was different from that seen in the ageing process or in the axonal reactions of controls with atonic bladder. In ALS, the morphometric findings for the Onuf's neurons showed no correlation with age at death, clinical duration, or number of PPL neurons. Our results indicate that in ALS Onuf's nucleus is principally vulnerable to the ALS process, although the degree of degeneration differs from that seen in other motor neurons. The involvement of Onuf's nucleus might be slowed due to factors specific to this nucleus, including the biochemical and autonomic properties of the nucleus; nevertheless, it is histologically classified as part of the somatic cell column. |
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AbstractList | The Onufrowicz (Onuf's) nuclei from eight amyotrophic lateral sclerosis (ALS) cases and nine neurological control cases were studied histologically and morphometrically. To clarify the factors relating to the involvement of the Onuf's nucleus in ALS, we correlated the relationships among the age at death, clinical duration, morphometric findings for Onuf's neurons, and neuronal numbers in the posteroposterolateral (PPL) nuclei in the ALS cases with those in neurological controls. Intracytoplasmic inclusions such as Bunina bodies, ubiquitin-reactive inclusions, and conglomerate inclusion were found in the Onuf's neurons in ALS, but not in the controls. The total number of Onuf's neurons in the ALS cases was not decreased, but that of normal-appearing neurons was decreased while that of atrophic neurons was increased. Significantly decreased perikaryal, nuclear and nucleolar areas and decreased perikaryal (P)/nuclear and P/nucleolar area ratios of Onuf's neurons were found in ALS, not only in the atrophic neurons but also in the normal-appearing neurons, compared with the controls. The shrinkage in Onuf's neurons of ALS was different from that seen in the ageing process or in the axonal reactions of controls with atonic bladder. In ALS, the morphometric findings for the Onuf's neurons showed no correlation with age at death, clinical duration, or number of PPL neurons. Our results indicate that in ALS Onuf's nucleus is principally vulnerable to the ALS process, although the degree of degeneration differs from that seen in other motor neurons. The involvement of Onuf's nucleus might be slowed due to factors specific to this nucleus, including the biochemical and autonomic properties of the nucleus; nevertheless, it is histologically classified as part of the somatic cell column. |
Author | Yoshimasu, Fumio Yase, Yoshiro Yoshida, Sohei Wakayama, Ikuro Kihira, Tameko |
Author_xml | – sequence: 1 givenname: Tameko surname: Kihira fullname: Kihira, Tameko organization: Division of Neurological Diseases, Wakayama Medical College, 9-Bancho, 27, Wakayama City, Japan, 640 – sequence: 2 givenname: Sohei surname: Yoshida fullname: Yoshida, Sohei organization: Division of Neurological Diseases, Wakayama Medical College, 9-Bancho, 27, Wakayama City, Japan, 640 – sequence: 3 givenname: Fumio surname: Yoshimasu fullname: Yoshimasu, Fumio organization: Department of Psychiatry, Wakayama Medical College, 9-Bancho, 27, Wakayama City, Japan 640 – sequence: 4 givenname: Ikuro surname: Wakayama fullname: Wakayama, Ikuro organization: Research Center of Neurological Diseases, Kansai College of Oriental Medicine, Osaka, Japan – sequence: 5 givenname: Yoshiro surname: Yase fullname: Yase, Yoshiro organization: Research Center of Neurological Diseases, Kansai College of Oriental Medicine, Osaka, Japan |
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Keywords | ALS Perikaryal area Onuf's nucleus Nucleolar area Morphometry Nuclear area Human Pathology Nervous system diseases Neuron Pathogenesis Central nervous system disease Posterolateral nucleus Amyotrophic lateral sclerosis Degenerative disease Histology Spinal cord disease |
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Snippet | The Onufrowicz (Onuf's) nuclei from eight amyotrophic lateral sclerosis (ALS) cases and nine neurological control cases were studied histologically and... |
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SubjectTerms | Adult Aged Aged, 80 and over ALS Amyotrophic Lateral Sclerosis - pathology Amyotrophic Lateral Sclerosis - physiopathology Anal Canal - innervation Biological and medical sciences Cell Count Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Male Medical sciences Middle Aged Morphometry Motor Neurons - pathology Motor Neurons - physiology Neurology Nuclear area Nucleolar area Onuf's nucleus Perikaryal area Urethra - innervation |
Title | Involvement of Onuf's nucleus in amyotrophic lateral sclerosis |
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