IgG reactivity to different desmoglein-3 ectodomains in pemphigus vulgaris: novel panels for assessing disease severity

• Published in: Frontiers in immunology Vol. 15; p. 1469937
• Main Authors: Tavakolpour, Soheil, Noormohammadi, Zahra, Daneshpazhooh, Maryam, Gholami, Alireza, Mahmoudi, Hamidreza
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 02.10.2024
• Subjects: Adult; Aged; Autoantibodies - blood; Autoantibodies - immunology; Desmoglein 3 - immunology; desmoglein-3; disease severity; ectodomains; ELISA; Enzyme-Linked Immunosorbent Assay; Female; HEK293 Cells; Humans; IgG autoantibodies; Immunoglobulin G - blood; Immunoglobulin G - immunology; Immunology; Male; Middle Aged; Pemphigus - blood; Pemphigus - diagnosis; Pemphigus - immunology; pemphigus vulgaris; Protein Domains; Severity of Illness Index; autoimmune; pemphigus vulgaris; IgG autoantibodies; desmoglein-3; PDAI; ectodomains; disease severity; ELISA
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2024.1469937

Pemphigus vulgaris (PV) is an autoimmune disease characterized by IgG autoantibodies targeting desmoglein-3 (Dsg3), leading to blistering of mucous membranes and skin. Although commercial ELISA kits effectively diagnose PV, correlation with clinical phenotype remains unclear. This study assesses mul...