miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model

• Published in: Toxicological sciences Vol. 161; no. 1; pp. 149 - 158
• Main Authors: Mosedale, Merrie, Eaddy, J Scott, Trask, O Joseph, Holman, Natalie S, Wolf, Kristina K, LeCluyse, Edward, Ware, Brenton R, Khetani, Salman R, Lu, Jingtao, Brock, William J, Roth, Sharin E, Watkins, Paul B
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.01.2018
• Subjects: EXOSOMAL RELEASE OF microRNA-122 IN TOLVAPTAN-INDUCED TOXICITY; apoptosis; mitochondrial dysfunction; idiosyncratic drug-induced liver injury (IDILI); oxidative stress; danger signal
• ISSN: 1096-6080; 1096-0929; 1096-0929
• DOI: 10.1093/toxsci/kfx206

Abstract Idiosyncratic drug-induced liver injury (IDILI) is thought to often result from an adaptive immune attack on the liver. However, it has been proposed that the cascade of events culminating in an adaptive immune response begins with drug-induced hepatocyte stress, release of exosomal danger...