Serotype-specific host responses in rhesus macaques after primary dengue challenge

• Published in: The American journal of tropical medicine and hygiene Vol. 89; no. 6; pp. 1043 - 1057
• Main Authors: Hickey, Andrew C, Koster, Jacob A, Thalmann, Claudia M, Hardcastle, Kathy, Tio, Phaik-Hooi, Cardosa, Mary J, Bossart, Katharine N
• Format: Journal Article
• Language: English
• Published: United States The American Society of Tropical Medicine and Hygiene 01.12.2013
• Subjects: Animals; Antibodies, Neutralizing - biosynthesis; Antibodies, Neutralizing - blood; Antibodies, Viral - biosynthesis; Antibodies, Viral - blood; Cercopithecus aethiops; Cytokines - blood; Dengue - immunology; Dengue - virology; Dengue virus; Dengue Virus - immunology; Female; Fibrin Fibrinogen Degradation Products - analysis; Fibrinogen - analysis; Hematologic Tests; Humans; Immunity, Humoral; Immunoglobulin G - biosynthesis; Immunoglobulin G - blood; Immunoglobulin M - biosynthesis; Immunoglobulin M - blood; Macaca mulatta; Male; Protein C - analysis; RNA, Viral - genetics; Severe Dengue - immunology; Severe Dengue - virology; Species Specificity; Vero Cells

Dengue virus (DENV) is considered to be the most important arthropod-borne viral disease and causes more than 100 million human infections annually. To further characterize primary DENV infection in vivo, rhesus macaques were infected with DENV-1, DENV-2, DENV-3, or DENV-4 and clinical parameters, a...