Structural-Functional Analysis of 2,1,3-Benzoxadiazoles and Their N-oxides As HIV-1 Integrase Inhibitors

• Published in: Actanaturae Vol. 5; no. 1; pp. 63 - 72
• Main Authors: Korolev, S P, Kondrashina, O V, Druzhilovsky, D S, Starosotnikov, A M, Dutov, M D, Bastrakov, M A, Dalinger, I L, Filimonov, D A, Shevelev, S A, Poroikov, V V, Agapkina, Y Y, Gottikh, M B
• Format: Journal Article
• Language: English
• Published: Russia (Federation) A.I. Gordeyev 01.01.2013
• Subjects: QikProp; inhibition; PASS; HIV-1 integrase; nitrobenzofurazan; nitrobenzofuroxan

Human immunodeficiency virus type 1 integrase is one of the most attractive targets for the development of anti-HIV-1 inhibitors. The capacity of a series of 2,1,3-benzoxadiazoles (benzofurazans) and their N-oxides (benzofuroxans) selected using the PASS software to inhibit the catalytic activity of...