Can self-powered piezoelectric materials be used to treat disc degeneration by means of electrical stimulation?
Intervertebral disc degeneration (IDD) due to multiple causes is one of the major causes of low back pain (LBP). A variety of traditional treatments and biologic therapies are currently used to delay or even reverse IDD; however, these treatments still have some limitations. Finding safer and more e...
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Published in | Frontiers in bioengineering and biotechnology Vol. 12; p. 1397261 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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09.05.2024
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Abstract | Intervertebral disc degeneration (IDD) due to multiple causes is one of the major causes of low back pain (LBP). A variety of traditional treatments and biologic therapies are currently used to delay or even reverse IDD; however, these treatments still have some limitations. Finding safer and more effective treatments is urgent for LBP patients. With increasing reports it has been found that the intervertebral disc (IVD) can convert pressure loads from the spine into electrical stimulation in a variety of ways, and that this electrical stimulation is of great importance in modulating cell behavior, the immune microenvironment and promoting tissue repair. However, when intervertebral disc degeneration occurs, the normal structures within the IVD are destroyed. This eventually leads to a weakening or loss of self-powered. Currently various piezoelectric materials with unique crystal structures can mimic the piezoelectric effect of normal tissues. Based on this, tissue-engineered scaffolds prepared using piezoelectric materials have been widely used for regenerative repair of various types of tissues, however, there are no reports of their use for the treatment of IDD. For this reason, we propose to utilize tissue-engineered scaffolds prepared from piezoelectric biomaterials with excellent biocompatibility and self-powered properties to be implanted into degenerated IVD to help restore cell type and number, restore extracellular matrix, and modulate immune responses. It provides a feasible and novel therapeutic approach for the clinical treatment of IDD. |
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AbstractList | Intervertebral disc degeneration (IDD) due to multiple causes is one of the major causes of low back pain (LBP). A variety of traditional treatments and biologic therapies are currently used to delay or even reverse IDD; however, these treatments still have some limitations. Finding safer and more effective treatments is urgent for LBP patients. With increasing reports it has been found that the intervertebral disc (IVD) can convert pressure loads from the spine into electrical stimulation in a variety of ways, and that this electrical stimulation is of great importance in modulating cell behavior, the immune microenvironment and promoting tissue repair. However, when intervertebral disc degeneration occurs, the normal structures within the IVD are destroyed. This eventually leads to a weakening or loss of self-powered. Currently various piezoelectric materials with unique crystal structures can mimic the piezoelectric effect of normal tissues. Based on this, tissue-engineered scaffolds prepared using piezoelectric materials have been widely used for regenerative repair of various types of tissues, however, there are no reports of their use for the treatment of IDD. For this reason, we propose to utilize tissue-engineered scaffolds prepared from piezoelectric biomaterials with excellent biocompatibility and self-powered properties to be implanted into degenerated IVD to help restore cell type and number, restore extracellular matrix, and modulate immune responses. It provides a feasible and novel therapeutic approach for the clinical treatment of IDD. |
Author | Liu, Xianyan Li, Zhonghai Huang, Huagui Wang, Jinzuo Wang, Kaizhong Suo, Moran Liu, Xin |
AuthorAffiliation | 1 Department of Orthopedics , First Affiliated Hospital of Dalian Medical University , Dalian , China 2 Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopedic Diseases , Dalian , China |
AuthorAffiliation_xml | – name: 1 Department of Orthopedics , First Affiliated Hospital of Dalian Medical University , Dalian , China – name: 2 Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopedic Diseases , Dalian , China |
Author_xml | – sequence: 1 givenname: Huagui surname: Huang fullname: Huang, Huagui organization: Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopedic Diseases, Dalian, China – sequence: 2 givenname: Kaizhong surname: Wang fullname: Wang, Kaizhong organization: Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopedic Diseases, Dalian, China – sequence: 3 givenname: Xianyan surname: Liu fullname: Liu, Xianyan organization: Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopedic Diseases, Dalian, China – sequence: 4 givenname: Jinzuo surname: Wang fullname: Wang, Jinzuo organization: Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopedic Diseases, Dalian, China – sequence: 5 givenname: Moran surname: Suo fullname: Suo, Moran organization: Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopedic Diseases, Dalian, China – sequence: 6 givenname: Xin surname: Liu fullname: Liu, Xin organization: Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopedic Diseases, Dalian, China – sequence: 7 givenname: Zhonghai surname: Li fullname: Li, Zhonghai organization: Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopedic Diseases, Dalian, China |
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Cites_doi | 10.1089/ten.tea.2008.0554 10.1097/brs.0b013e3182a211e3 10.1002/adfm.201910108 10.1088/0957-4484/25/48/485101 10.1115/1.1286316 10.1016/j.msec.2017.03.007 10.1016/j.actbio.2018.04.026 10.1016/j.mehy.2017.07.021 10.3389/fbioe.2021.766087 10.1016/j.jbiomech.2006.10.001 10.34133/2019/9025939 10.1016/s0140-6736(18)30480-x 10.1007/s12551-021-00779-9 10.1038/s41598-019-42320-9 10.1038/s41598-018-30185-3 10.1097/00007632-200105150-00017 10.1002/adhm.202300318 10.1007/s00253-012-4353-0 10.1002/jsp2.1026 10.1097/00007632-199109000-00001 10.1016/0021-9290(94)00159-2 10.1002/adma.202008452 10.1016/j.mcna.2014.01.003 10.1016/j.actbio.2015.07.010 10.1016/j.bioactmat.2021.04.016 10.1007/s10856-009-3734-0 10.1002/jsp2.1213 10.1186/s41232-018-0059-8 10.1007/s00403-011-1145-9 10.1016/j.jbiomech.2020.109622 10.1097/brs.0000000000004331 10.1097/00007632-200005010-00011 10.1186/s40779-023-00469-5 10.3390/mi12111291 10.1177/0269215514540919 10.1021/jm501981g 10.3390/ijms231710122 10.1016/j.mtbio.2024.100950 10.1016/j.gene.2005.10.028 10.1007/s00586-016-4439-y 10.1002/jsp2.1076 10.1186/s40824-019-0176-8 10.1016/j.spinee.2016.01.003 10.3390/cells11030394 10.2174/1574888x10666150113112149 10.1038/nmat5045 |
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Keywords | intervertebral disc degeneration piezoelectric materials intervertebral disc piezoelectricity mechanotransduction |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Xuesong Zhu, The First Affiliated Hospital of Soochow University, China Reviewed by: Hongfei Xiang, The Affiliated Hospital of Qingdao University, China These authors have contributed equally to this work Edited by: Martijn Van Griensven, Maastricht University, Netherlands |
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Snippet | Intervertebral disc degeneration (IDD) due to multiple causes is one of the major causes of low back pain (LBP). A variety of traditional treatments and... |
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SubjectTerms | Bioengineering and Biotechnology intervertebral disc intervertebral disc degeneration mechanotransduction piezoelectric materials piezoelectricity |
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Title | Can self-powered piezoelectric materials be used to treat disc degeneration by means of electrical stimulation? |
URI | https://www.ncbi.nlm.nih.gov/pubmed/38784767 https://www.proquest.com/docview/3060380740/abstract/ https://pubmed.ncbi.nlm.nih.gov/PMC11111946 https://doaj.org/article/f2ff8eb20e394195bcef784350e928ae |
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