The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways

• Published in: Biochemical and biophysical research communications Vol. 373; no. 4; pp. 545 - 549
• Main Authors: Ahn, Jiyun, Lee, Hyunjung, Kim, Suna, Park, Jaeho, Ha, Taeyoul
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.09.2008
• Subjects: 3T3-L1 adipocyte; 3T3-L1 Cells; Acetyl-CoA Carboxylase - metabolism; Adipocytes - drug effects; Adipocytes - enzymology; Adipogenesis; Adipogenesis - drug effects; AMPK; Animals; Anti-Obesity Agents - pharmacology; Antioxidants - pharmacology; Apoptosis; MAPK; Mice; Mitogen-Activated Protein Kinases - metabolism; Protein Kinases - metabolism; Quercetin; Quercetin - pharmacology; AMPK; MAPK; 3T3-L1 adipocyte; Quercetin; Adipogenesis; Apoptosis

Quercetin is the most abundant flavonoid and is assumed to have protective roles against the pathogenesis of multiple diseases associated with oxidative stress. In the present study, we investigated the molecular mechanisms by which quercetin affects adipogenesis and apoptosis in 3T3-L1 cells. The e...