Outer membrane permeability of mcr-positive bacteria reveals potent synergy of colistin and macromolecular antibiotics against colistin-resistant Acinetobacter baumannii

• Published in: Frontiers in microbiology Vol. 15; p. 1468682
• Main Authors: Li, Meisong, Ma, Furong, Zhao, Hui, Zhou, Dianrong, Liang, Lujie, Lv, Runling, Li, Jiachen, Wang, Yaxuan, Xu, Lin, Liu, Chenfei, Tian, Guo-Bao, Feng, Siyuan, Xia, Yong
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 19.11.2024
• Subjects: Acinetobacter baumannii; colistin; MCR; Microbiology; outer membrane permeability; rifampicin; rifampicin; Acinetobacter baumannii; MCR; outer membrane permeability; colistin

Colistin (CT) is the last-resort of antibiotic against multidrug-resistance (MDR) Acinetobacter baumannii ( A. baumannii ) infection. However, colistin resistance is increasingly reported in A. baumannii isolates partially due to the global emergence and dissemination of plasmid-borne mobile colisti...