Disability evaluation in patients with Guillain-Barre syndrome and SARS-CoV-2 infection

Several cases of Guillain-Barre syndrome (GBS) associated with SARS-CoV-2 infection have been described. This study illustrated the demographic, clinical, and neurophysiological characteristics of patients with GBS and COVID-19, as well as associated factors with disability at discharge. A retrospec...

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Published inFrontiers in neurology Vol. 14; p. 1191520
Main Authors Sanchez-Boluarte, Sofía S., Aguirre-Quispe, Wilfor, Tacunan-Cuellar, Jhon, Sanchez-Boluarte, Arantxa N., Segura-Chavez, Darwin
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 29.06.2023
Subjects
COVID-19
disability evaluation
Guillain-Barre syndrome
Neurology
polyneuropathy
SARS-CoV-2
COVID-19
SARS-CoV-2
Guillain-Barre syndrome
disability evaluation
polyneuropathy
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Summary:Several cases of Guillain-Barre syndrome (GBS) associated with SARS-CoV-2 infection have been described. This study illustrated the demographic, clinical, and neurophysiological characteristics of patients with GBS and COVID-19, as well as associated factors with disability at discharge. A retrospective analytical observational study was conducted. It included patients diagnosed with GBS admitted in a national reference center in Peru between 2019 and 2021. Epidemiological, clinical, neurophysiological, and cerebrospinal fluid data were analyzed. A multivariate analysis, using the generalized linear model, was performed, considering the presence of disability at discharge as the dependent variable. Eight-one subjects diagnosed with GBS were included. The mean age was 46.8 years (SD: 15.2), with a predominance of males (61.73%). The most frequent clinical presentation was the classic sensory-motor form in 74 cases (91.36%) with AIDP (82.35%) as the most frequent neurophysiological pattern in the group with COVID-19, while AMAN pattern predominated (59.26%) in those without COVID-19 (  = <0.000). The disability prevalence ratio at discharge between subjects with COVID-19 and those without COVID-19 was 1.89 (CI 1.06-3.34),  = 0.030, adjusted for age, sex, and neurophysiological subtype. The neurophysiologic subtype AIDP, and a higher disability were associated with the presence of COVID-19.
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Edited by: Giovanni Meola, University of Milan, Italy
Reviewed by: Nakul Katyal, Stanford Healthcare, United States; Aleksandra S. Kacar, University of Belgrade, Serbia
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2023.1191520