Selected stem cell populations in pediatric acute lymphoblastic leukemia

• Published in: Frontiers in immunology Vol. 15; p. 1446687
• Main Authors: Krętowska-Grunwald, Anna, Sawicka-Żukowska, Małgorzata, Starosz, Aleksandra, Krawczuk-Rybak, Maryna, Moniuszko, Marcin, Grubczak, Kamil
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 25.09.2024
• Subjects: acute lymphoblastic leukemia; Adolescent; Child; Child, Preschool; Female; Flow Cytometry; hematopoietic stem cells; Hematopoietic Stem Cells - pathology; Humans; Immunology; Infant; Male; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology; regenerative medicine; Retrospective Studies; stromal cell-derived factor 1; very small embryonic-like stem cells; very small embryonic-like stem cells; hematopoietic stem cells; acute lymphoblastic leukemia; regenerative medicine; stromal cell-derived factor 1

Acute lymphoblastic leukemia is characterized by a disturbed maturation of hematopoietic stem cells (HSCs) resulting in development of a malignant clone. Despite relatively positive outcome, there are still instances of disease relapse occurring due to ineffective disease eradication or primary leuk...