Injectable and Tunable Gelatin Hydrogels Enhance Stem Cell Retention and Improve Cutaneous Wound Healing

• Published in: Advanced functional materials Vol. 27; no. 24
• Main Authors: Dong, Yixiao, A, Sigen, Rodrigues, Melanie, Li, Xiaolin, Kwon, Sun H., Kosaric, Nina, Khong, Sacha, Gao, Yongsheng, Wang, Wenxin, Gurtner, Geoffrey C.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 27.06.2017
• Subjects: Biodegradability; Encapsulation; gelatin; Gelation; Hydrogels; hyperbranched polymers; injectable hydrogels; Materials science; Mechanical properties; Medical research; Polyethylene glycol; Regeneration; Stem cells; Tissue engineering; Wound healing

Stem cells have shown substantial promise for various diseases in preclinical and clinical trials. However, low cell engraftment rates significantly limit the clinical translation of stem cell therapeutics. Numerous injectable hydrogels have been developed to enhance cell retention. Yet, the design...