Scalable Electrochemical Transition‐Metal‐Free Dehydrogenative Cross‐Coupling Amination Enabled Alkaloid Clausines Synthesis

• Published in: Advanced synthesis & catalysis Vol. 362; no. 12; pp. 2342 - 2347
• Main Authors: Zhang, Pan, Li, Baoying, Niu, Liwei, Wang, Ling, Zhang, Guofeng, Jia, Xiaofei, Zhang, Guoying, Liu, Siyuan, Ma, Li, Gao, Wei, Qin, Dawei, Chen, Jianbin
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 15.06.2020; Wiley Subscription Services, Inc
• Subjects: alkaloid clausines; amination; Carbazoles; Chemistry; Chemistry, Applied; Chemistry, Organic; Cross coupling; C−H activation; Dehydrogenation; dehydrogenative cross-coupling; electrosynthesis; Hydrogen bonds; Oxidizing agents; Physical Sciences; Science & Technology; PALLADIUM; ACTIVATION; COMPLEX; DESIGN; electrosynthesis; alkaloid clausines; CATALYZED SYNTHESIS; dehydrogenative cross-coupling; C-H activation; CARBAZOLE; OXIDATIONS; amination; N BOND FORMATION; DERIVATIVES; C-H AMINATION

Reported herein is an environmentally benign electrochemical C−H bond dehydrogenative amination protocol for the construction of privileged carbazole moiety with broad generality. Preliminary mechanistic investigations implied a radical reaction pathway. Compared with traditional ionic routes, the s...