Synthesis of Fluoromethyl‐Substituted Isoxazolines via Transition Metal‐Free Oxyfluorination of Alkenyl Oximes

A mild and efficient transition metal‐free intramolecular oxyfluorination of alkenyl oximes is demonstrated. The reaction tolerates a range of substrates to give a series of monofluoromethylated isoxazoline derivatives with good yields. The possible pathways are proposed based on the reaction result...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 359; no. 10; pp. 1626 - 1630
Main Authors Zhao, Juan, Jiang, Min, Liu, Jin‐Tao
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 17.05.2017
Wiley Subscription Services, Inc
Subjects
alkenyl oximes
Chemistry
Chemistry, Applied
Chemistry, Organic
intramolecular reaction
isoxazolines
Oximes
oxyfluorination
Physical Sciences
Science & Technology
Substrates
transition metal-free conditions
isoxazolines
ACTIVATION
ELECTROPHILIC FLUORINATION
SELECTIVE FLUORINATION
COPPER-MEDIATED DIFLUOROMETHYLATION
FLUOROALKYLATION
DRUG DESIGN
oxyfluorination
alkenyl oximes
IODIDES
LIQUID-CRYSTALS
ARYL
MONOFLUOROMETHYLATION
transition metal-free conditions
intramolecular reaction
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Summary:A mild and efficient transition metal‐free intramolecular oxyfluorination of alkenyl oximes is demonstrated. The reaction tolerates a range of substrates to give a series of monofluoromethylated isoxazoline derivatives with good yields. The possible pathways are proposed based on the reaction results and control experiments.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201601405