The use of erythrocyte fragility to assess xenobiotic cytotoxicity

• Published in: Cell biochemistry and function Vol. 33; no. 6; pp. 351 - 355
• Main Authors: Pagano, Maria, Faggio, Caterina
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.08.2015; Wiley Subscription Services, Inc
• Subjects: Animals; blood; Cytotoxicity; cytotoxicity assay; eryptosis; Erythrocyte Membrane - metabolism; Erythrocytes; Erythrocytes - cytology; Erythrocytes - drug effects; Erythrocytes - metabolism; haemolysis; Hemoglobins - metabolism; Hemolysis; Humans; Mammals; Toxicity Tests - methods; xenobiotic; Xenobiotics - metabolism; Xenobiotics - toxicity; eryptosis; erythrocytes; haemolysis; xenobiotic; blood; cytotoxicity assay

The erythrocytes of mammals represent a good model to evaluate the cytotoxicity of molecules, organic and inorganic, natural or synthetic, by cellular damage measure. Indeed, before any investigation on the mechanism of action of different molecules, it is important to perform a cytotoxicity assay....