Review: Biological relevance of disseminated tumor cells in cancer patients

• Published in: International journal of cancer Vol. 123; no. 9; pp. 1991 - 2006
• Main Authors: Riethdorf, Sabine, Wikman, Harriet, Pantel, Klaus
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2008
• Subjects: bone marrow; Bone Marrow - pathology; breast cancer; Breast Neoplasms - pathology; CD24 Antigen - analysis; colorectal cancer; Colorectal Neoplasms - pathology; disseminated tumor cells; Female; Humans; Hyaluronan Receptors - analysis; Immunohistochemistry; lung cancer; Lung Neoplasms - pathology; Male; metastasis; Neoplasm, Residual; Neoplasms - pathology; Neoplastic Cells, Circulating; prostate cancer; Prostatic Neoplasms - pathology; Receptor, ErbB-2 - analysis; Reverse Transcriptase Polymerase Chain Reaction; USA; Europe

The prognosis of cancer patients is largely determined by the occurrence of distant metastases. In patients with primary tumors, this relapse is mainly due to clinically occult micrometastasis present in secondary organs at primary diagnosis but not detectable even with high resolution imaging proce...