Global DNA Methylation and Histone Posttranslational Modifications in Human and Nonhuman Primate Brain in Association with Prenatal Alcohol Exposure

• Published in: Alcoholism, clinical and experimental research Vol. 43; no. 6; pp. 1145 - 1162
• Main Authors: Jarmasz, Jessica S., Stirton, Hannah, Basalah, Duaa, Davie, James R., Clarren, Sterling K., Astley, Susan J., Del Bigio, Marc R.
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.06.2019
• Subjects: Acetylation; Epigenetics; Human Brain; Methylation; Original; Pathology, Immunology and Development; Prenatal Alcohol; Epigenetics; Acetylation; Human Brain; Methylation; Prenatal Alcohol
• ISSN: 0145-6008; 1530-0277; 1530-0277
• DOI: 10.1111/acer.14052

Background Based upon experimental animal studies, the neurodevelopmental abnormalities associated with prenatal alcohol exposure (PNAE)/fetal alcohol spectrum disorder (FASD) have been attributed, at least in part, to epigenetic modifications. However, there are no direct analyses of human brain ti...