Monitoring of von Willebrand factor inhibitors in patients with type 3 von Willebrand disease using a quantitative assay

• Published in: Haemophilia : the official journal of the World Federation of Hemophilia Vol. 27; no. 5; pp. 823 - 829
• Main Author: Miller, Connie H.
• Format: Journal Article
• Language: English
• Published: Chichester Wiley Subscription Services, Inc 01.09.2021
• Subjects: Agglutination; Coagulation factors; factor VIII; Heat treatments; Immunological tolerance; inhibitor; Patients; Platelets; Ristocetin; von Willebrand disease; Von Willebrand factor

Background Antibodies inhibiting von Willebrand factor (VWF) develop in a subset of patients with type 3 von Willebrand disease (VWD3) and may be detected by their inhibition of ristocetin cofactor activity (VWF:RCo). Some also inhibit factor VIII activity (VIII:C). Aim To describe monitoring of ten...