Structural analysis of 2-arylidene-1-indanone derivatives by electrospray ionization tandem mass spectrometry

• Published in: Rapid communications in mass spectrometry Vol. 27; no. 21; pp. 2461 - 2471
• Main Authors: Menezes, José C. J. M. D. S., Cavaleiro, José A. S., Domingues, M. Rosário M.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 15.11.2013; Wiley Subscription Services, Inc
• Subjects: Cholinesterase Inhibitors - chemistry; Derivatives; Drugs; Fragmentation; Indans - chemistry; Inhibitors; Ionization; Mass spectrometry; Medical services; Pathways; Piperidines - chemistry; Spectrometry, Mass, Electrospray Ionization - methods

RATIONALE 2‐arylidene‐4‐methoxy (or hydroxy)‐7‐methyl‐1‐indanone derivatives inspired from donepezil, the current drug used for the treatment of Alzheimer's disease as inhibitor of acetylcholinesterase (AChE), were studied for the first time by electrospray ionization mass spectrometry (ESI‐MS)...