Fine‐mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 63; no. 6; pp. 1689 - 1697
• Main Authors: Hughes, Travis, Kim‐Howard, Xana, Kelly, Jennifer A., Kaufman, Kenneth M., Langefeld, Carl D., Ziegler, Julie, Sanchez, Elena, Kimberly, Robert P., Edberg, Jeffrey C., Ramsey‐Goldman, Rosalind, Petri, Michelle, Reveille, John D., Martín, Javier, Brown, Elizabeth E., Vilá, Luis M., Alarcón, Graciela S., James, Judith A., Gilkeson, Gary S., Moser, Kathy L., Gaffney, Patrick M., Merrill, Joan T., Vyse, Timothy J., Alarcón‐Riquelme, Marta E., Nath, Swapan K., John B. Harley, Sawalha, Amr H.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2011; Wiley; Wiley Subscription Services, Inc
• Subjects: Biological and medical sciences; Black or African American; Black People - genetics; Chromosome Mapping; Chromosomes, Human, Pair 4 - genetics; Cohort Studies; Dermatology; Diseases of the osteoarticular system; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-2 - genetics; Interleukin-21; Interleukins - genetics; Lupus Erythematosus, Systemic - epidemiology; Lupus Erythematosus, Systemic - genetics; Medical sciences; Polymorphism, Single Nucleotide; Skin involvement in other diseases. Miscellaneous. General aspects; White People - genetics; Lupus; Cartography; Skin disease; Rheumatology; Interleukin 21; Genotype; Genetics

Objective Genetic association of the IL2/IL21 region at chromosome 4q27 has previously been reported in lupus and a number of autoimmune and inflammatory diseases. This study was undertaken to determine whether this genetic effect could be localized, using a very large cohort of lupus patients and c...