CEPHALOSPORINS HAVING A HETEROCYCLIC CATECHOL IN THE C3 SIDE CHAIN I. ENHANCEMENT OF EFFICACY AGAINST GRAM-NEGATIVE BACTERIA

• Published in: Journal of antibiotics Vol. 46; no. 5; pp. 840 - 849
• Main Authors: KAMACHI, HAJIME, HASEGAWA, TOSHIFUMI, KAMEI, HIDEO, IMAE, KIYOTO, OKITA, TAKAAKI, HIRANO, MINORU, IIMURA, SEIJI
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1993; Japan Antibiotics Research Association
• Subjects: Animals; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Ceftazidime - pharmacology; Cephalosporins - chemical synthesis; Cephalosporins - pharmacokinetics; Cephalosporins - pharmacology; Half-Life; Imipenem - pharmacology; Medical sciences; Mice; Microbial Sensitivity Tests; Pharmacology. Drug treatments; Pseudomonas Infections - drug therapy; Stereoisomerism; Structure-Activity Relationship; Microorganism growth; Molecular structure; Rodentia; Lactam; In vitro; Chemical substitution; Infection; In vivo; Vertebrata; Chemotherapy; Cephalosporin derivatives; Mammalia; Sensitivity resistance; Synthesis; Treatment; Structure activity relation; Mouse; Animal; Bacteriosis; Bacteria; Comparative study; Heterocyclic compound

Two groups of cephalosporins substituted with a variety of heterocyclic catechols in the C3 side chain were synthesized. One is a group of 3-(heterocyclic catechol-substituted methyl)cephalosporins and another is 3-[(E)-3-heterocyclic catechol-substituted l-propen-l-yl]cephalosporins. Cephalosporins...