CEPHALOSPORINS HAVING A HETEROCYCLIC CATECHOL IN THE C3 SIDE CHAIN: I. ENHANCEMENT OF EFFICACY AGAINST GRAM-NEGATIVE BACTERIA - KAMACHI, HAJIME; HASEGAWA, TOSHIFUMI; KAMEI, HIDEO; IMAE, KIYOTO; OKITA, TAKAAKI; HIRANO, MINORU; IIMURA, SEIJI (Journal of antibiotics, 1993)
Keywords: Animals; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Ceftazidime - pharmacology; Cephalosporins - chemical synthesis; Cephalosporins - pharmacokinetics; Cephalosporins - pharmacology; Half-Life; Imipenem - pharmacology; Medical sciences; Mice; Microbial Sensitivity Tests; Pharmacology. Drug treatments; Pseudomonas Infections - drug therapy; Stereoisomerism; Structure-Activity Relationship; Microorganism growth; Molecular structure; Rodentia; Lactam; In vitro; Chemical substitution; Infection; In vivo; Vertebrata; Chemotherapy; Cephalosporin derivatives; Mammalia; Sensitivity resistance; Synthesis; Treatment; Structure activity relation; Mouse; Animal; Bacteriosis; Bacteria; Comparative study; Heterocyclic compound