Non-medullary Thyroid Cancer Susceptibility Genes: Evidence and Disease Spectrum

• Published in: Annals of surgical oncology Vol. 28; no. 11; pp. 6590 - 6600
• Main Authors: Zhou, Jingan, Singh, Preeti, Yin, Kanhua, Wang, Jin, Bao, Yujia, Wu, Menghua, Pathak, Kush, McKinley, Sophia K., Braun, Danielle, Lubitz, Carrie C., Hughes, Kevin S.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.10.2021; Springer Nature B.V
• Subjects: Adenomatous polyposis coli; Breast cancer; Colorectal carcinoma; Disease; Endocrine Tumors; Gastric cancer; Gastrointestinal cancer; Genes; Genetic Predisposition to Disease; Genetic resources; Germ-Line Mutation; Heredity; Humans; Kidney cancer; Literature reviews; Medicine; Medicine & Public Health; Oncology; Paraganglioma; Pheochromocytoma; PTEN protein; Surgery; Surgical Oncology; Susceptibility; Thyroid cancer; Thyroid Cancer, Papillary - genetics; Thyroid Neoplasms - genetics; Thyroid transcription factor 1; Tumors

Background The prevalence of non-medullary thyroid cancer (NMTC) is increasing worldwide. Although most NMTCs grow slowly, conventional therapies are less effective in advanced tumors. Approximately 5–15% of NMTCs have a significant germline genetic component. Awareness of the NMTC susceptibility ge...