Pyrrolidine dithiocarbamate reduces ischemia-reperfusion injury of the small intestine

• Published in: World journal of gastroenterology : WJG Vol. 11; no. 46; pp. 7308 - 7313
• Main Authors: Mallick, Ismail H, Yang, Wen-Xuan, Winslet, Marc C, Seifalian, Alexander M
• Format: Journal Article
• Language: English
• Published: United States Department of Surgery, Royal Free Hospital Hampstead NHS Trust, London, United Kingdom%GI and Hepatobiliary Research Unit, University Department of Surgery, Royal Free and University College Medical School, University College London, London,United Kingdom 14.12.2005; GI and Hepatobiliary Research Unit, University Department of Surgery, Royal Free and University College Medical School, University College London, London,United Kingdom; Baishideng Publishing Group Inc
• Subjects: Animals; Enzyme Induction - drug effects; Heme Oxygenase (Decyclizing) - biosynthesis; Intestine, Small - blood supply; Intestine, Small - enzymology; Intestine, Small - injuries; Male; Microcirculation - drug effects; Pyrrolidines - pharmacology; Rapid Communication; Rats; Rats, Sprague-Dawley; Reperfusion Injury - enzymology; Reperfusion Injury - pathology; Reperfusion Injury - prevention & control; Thiocarbamates - pharmacology; Ischemia-reperfusion injury; Pyrrolidine; Intestine; Heme oxygenase

To evaluate whether pyrrolidine dithiocarbamate (PDTC), an enhancer of HO production, attenuates intestinal IR injury. Eighteen male rats were randomly allocated into three groups: (a) sham; (b) IR, consisting of 30 min of intestinal ischemia, followed by 2-h period of reperfusion; and (c) PDTC trea...