Monoclonal antibody against the poly-γ-d-glutamic acid capsule of Bacillus anthracis protects mice from enhanced lethal toxin activity due to capsule and anthrax spore challenge

• Published in: Biochimica et biophysica acta Vol. 1830; no. 3; pp. 2804 - 2812
• Main Authors: Jang, Jeyoun, Cho, Minhui, Lee, Hae-Ri, Cha, Kiweon, Chun, Jeong-Hoon, Hong, Kee-Jong, Park, Jungchan, Rhie, Gi-eun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2013
• Subjects: Animals; anthrax; Anthrax - immunology; Anthrax - microbiology; Anthrax - mortality; Anthrax - prevention & control; Anthrax Vaccines - administration & dosage; Antibodies, Bacterial - administration & dosage; Antibodies, Bacterial - biosynthesis; Antibodies, Monoclonal - administration & dosage; Antibodies, Monoclonal - biosynthesis; antigens; Antigens, Bacterial - immunology; Bacillus anthracis; Bacillus anthracis - drug effects; Bacillus anthracis - immunology; Bacillus anthracis - pathogenicity; bacteria; Bacterial Capsules - immunology; Bacterial Toxins - immunology; blood; Cells, Cultured; cognition; complement; cytotoxicity; encapsulation; Female; Humans; immunization; Immunization, Passive; Kinetics; Lethal toxin; macrophages; Macrophages - drug effects; Macrophages - immunology; Macrophages - microbiology; Mice; Mice, Inbred BALB C; Modeling; Molecular Docking Simulation; monitoring; monoclonal antibodies; Monoclonal antibody; pathogenesis; Poly-γ-d-glutamic acid capsule; Polyglutamic Acid - analogs & derivatives; Polyglutamic Acid - antagonists & inhibitors; Polyglutamic Acid - immunology; spores; Spores, Bacterial - drug effects; Spores, Bacterial - immunology; Spores, Bacterial - pathogenicity; Survival Analysis; virulence; Virulence Factors - antagonists & inhibitors; Virulence Factors - immunology; EF; Bacillus anthracis; Poly-γ-d-glutamic acid capsule; HRP; MAPKK; LT; i.p; Lethal toxin; PGA; Monoclonal antibody; MAPK; Modeling; mAb; PA; 3D; LF

The poly-γ-d-glutamic acid (PGA) capsule, a major virulence factor of Bacillus anthracis, protects bacilli from immune surveillance and allows its unimpeded growth in the host. Recently, the importance of the PGA in the pathogenesis of anthrax infection has been reported. The PGA capsule is associat...