Oxidized quercetin inhibits α-synuclein fibrillization

• Published in: Biochimica et biophysica acta Vol. 1830; no. 4; pp. 2872 - 2881
• Main Authors: Zhu, Min, Han, Shubo, Fink, Anthony L.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2013
• Subjects: Aggregation; alpha-Synuclein - chemistry; antioxidant activity; antioxidants; atomic force microscopy; dopamine; high performance liquid chromatography; Hydrophilicity; Inhibition; isomers; light scattering; Microscopy, Atomic Force; Oxidation-Reduction; oxidative stress; Parkinson disease; Parkinson's disease; Protein Multimerization; Quercetin; Quercetin - pharmacology; risk factors; α-Synuclein; Aggregation; α-Synuclein; Parkinson's disease; Inhibition; Hydrophilicity; Quercetin

α-Synucein is a small (14kDa), abundant, intrinsically disordered presynaptic protein, whose aggregation is believed to be a critical step in Parkinson's disease (PD). Oxidative stress is reported to be a risk factor for dopamine cell degeneration in PD. Flavonoids are suggested to be important...