Treatment with pharmacological PPARα agonists stimulates the ubiquitin proteasome pathway and myofibrillar protein breakdown in skeletal muscle of rodents - Ringseis, Robert; Keller, Janine; Lukas, Isabel; Spielmann, Julia; Most, Erika; Couturier, Aline; König, Bettina; Hirche, Frank; Stangl, Gabriele I.; Wen, Gaiping; Eder, Klaus (Biochimica et biophysica acta, 2013)
Keywords: agonists; Animals; Anticholesteremic Agents - adverse effects; Anticholesteremic Agents - pharmacology; Atrogin-1; clofibrate; Clofibrate - adverse effects; Clofibrate - pharmacokinetics; gels; gene expression regulation; Humans; Hyperlipidemias - drug therapy; Hyperlipidemias - genetics; Hyperlipidemias - metabolism; messenger RNA; Mice; Mice, Knockout; MuRF1; Muscle atrophy; Muscle Proteins - genetics; Muscle Proteins - metabolism; Muscle, Skeletal - metabolism; Muscle, Skeletal - pathology; muscles; muscular atrophy; Muscular Atrophy - chemically induced; Muscular Atrophy - genetics; Muscular Atrophy - metabolism; Muscular Atrophy - pathology; patients; Peroxisome proliferator-activated receptor α; PPAR alpha - antagonists & inhibitors; PPAR alpha - genetics; PPAR alpha - metabolism; proteasome endopeptidase complex; Proteasome Endopeptidase Complex - genetics; Proteasome Endopeptidase Complex - metabolism; protein degradation; proteins; Proteolysis - drug effects; Pyrimidines - adverse effects; Pyrimidines - pharmacology; Rats; reporter genes; signal transduction; Signal Transduction - drug effects; Signal Transduction - genetics; skeletal muscle; transcription (genetics); transcription factors; Transcription, Genetic - drug effects; Transcription, Genetic - genetics; ubiquitin; Ubiquitin - genetics; Ubiquitin - metabolism; Ubiquitin proteasome system; ubiquitin-protein ligase; ubiquitination; Ubiquitination - drug effects; Ubiquitination - genetics; Up-Regulation - drug effects; Up-Regulation - genetics; 3-MH; Muscle atrophy; RXRα; DTT; CPT; MuRF1; ChIP; EDL; PPARα; Peroxisome proliferator-activated receptor α; PI3K; ACOX; CTSL; Atrogin-1; PPRE; Ubiquitin proteasome system; UPS; FoxO1